Altered postprandial motility in chronic pancreatitis: role of malabsorption
| Autor: | D. Grandt, P.G. Layer, Harald Goebell, Gerald Holtmann, M.R. von der Ohe, Jens J. Holst, Jan B.M.J. Jansen |
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| Rok vydání: | 1997 |
| Předmět: |
Adult
Blood Glucose Male medicine.medical_specialty Pancreatic disease Malabsorption Motility Gastroenterology Intestinal absorption Nutrition secretion and motility Eating Reference Values Voeding secretie en motoriek Internal medicine Intestine Small medicine Humans Nutritional Physiological Phenomena Hepatology Gastric emptying business.industry digestive oral and skin physiology Middle Aged medicine.disease Hormones Endocrinology Postprandial Intestinal Absorption Pancreatitis Chronic Disease Pancreatin Digestion Female Gastrointestinal Motility business Perfusion Biomarkers |
| Zdroj: | Europe PubMed Central CIÊNCIAVITAE Gastroenterology, 112, 5, pp. 1624-1634 Gastroenterology, 112, 1624-1634 |
| ISSN: | 0016-5085 |
| Popis: | BACKGROUND & AIMS: Intraileal nutrients modulate gastrointestinal motility, but effects of maldigestion on postprandial motility are unknown. The aim of this study was to compare motor responses with ileal nutrient exposure in health and pancreatic insufficiency after a meal or intraluminal perfusion. METHODS: After oroileal multilumen intubation for duodeno-jejuno-ileal sampling, marker perfusion, and motility recording, 14 normal subjects and 12 patients with severe pancreatic insufficiency received a labeled liquid meal twice, either with placebo or pancreatin. Effects of intraileal nutrient perfusion on fed motility induced by duodenal amino acid perfusion were also investigated. RESULTS: Compared with normals, untreated patients had greater cumulative ileal nutrient delivery (69 +/- 21 vs. 487 +/- 232 kJ), shorter fed pattern (196 +/- 22 vs. 131 +/- 14 minutes), greater 90% gastric emptying (163 +/- 12 vs. 128 +/- 10 minutes), and faster small intestinal transit (86 +/- 9 vs. 44 +/- 6 minutes). Pancreatin reversed these changes. Ileal nutrient perfusion converted fed into interdigestive-like motility in normals (7 of 8) and patients (4 of 5). CONCLUSIONS: In subjects with pancreatic insufficiency, a low-energy liquid meal induces shorter fed motor pattern associated with accelerated gastric emptying and intestinal transit compared with healthy subjects. Because changes responded to enzyme treatment and could be reproduced by ileal nutrient perfusion, ileal delivery of malabsorbed chyme may be involved as a mechanism. (Gastroenterology 1997 May;112(5):1624-34) |
| Databáze: | OpenAIRE |
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