3D RINEPT {1H}-31P CSI: A feasible approach for the study of membrane turnover in the human brain

Autor: Tim Wokrina, Wolfgang Weber-Fahr, Marco Ulrich, Gabriele Ende
Rok vydání: 2008
Předmět:
Zdroj: Magnetic Resonance in Medicine. 59:999-1004
ISSN: 1522-2594
0740-3194
DOI: 10.1002/mrm.21588
Popis: A fast, full 3D elliptical k-space encoding phosphorous-31 (31P) chemical shift imaging sequence, incorporating heteronuclear polarization transfer editing (RINEPT), was established. RINEPT literally requires simultaneous pulses at the frequencies of both the sensitive and the insensitive nuclei, but only a few MR imaging systems feature a second independent transmit channel. In this study, possible signal degradation of a sequential sequence design on systems featuring a single transmit channel was investigated with spin density matrix calculations and phantom measurements. In addition, metabolite signal intensities were determined in vivo as a function of echo and repetition times. The results enable optimization of the signal-to-noise ratio of one or more metabolites of interest. The results convincingly show that the optimized RINEPT sequence is useful in clinical routine 31PMRS protocols and provides spectra of excellent quality for the study of cell membrane phospholipid turnover in the human brain even at a low field strength of 1.5T. The 3D sequence design allows covering the whole brain in a single measurement, while scan times are compliant with clinical routine protocols. Magn Reson Med 59:999–1004, 2008. © 2008 Wiley-Liss, Inc.
Databáze: OpenAIRE
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