Influence of Omega-3 Fatty Acid-Rich Fish Oils on Hyperlipidemia: Effect of Eel, Sardine, Trout, and Cod Oils on Hyperlipidemic Mice
| Autor: | Lykourgos Klamarias, Martha Kontostathi, Vassilios Vasdekis, Vassilios Roussis, Jane Anastassopoulou, Dimitrios Mostratos, Nikolaos Demertzis, T. Theophanides, Evangelos Polychronopoulos, Sofia Isou, Dimitrios Melissos, Georgios-Theodorou Papaioannou, Evangelos Karalis, Angeliki P. Kourounakis, Fotini Dania, Andreas Vitsos, Homer S. Black, Maria Kyriazi, Charilaos Tsitouris, Michail-Christou Rallis |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
0301 basic medicine
anti-hyperlipidemia effect Trout Medicine (miscellaneous) Hyperlipidemias 03 medical and health sciences chemistry.chemical_compound Mice 0302 clinical medicine High-density lipoprotein Fish Oils Hyperlipidemia Fatty Acids Omega-3 medicine Animals Food science Omega 3 fatty acid chemistry.chemical_classification 030109 nutrition & dietetics Nutrition and Dietetics Eels biology omega-3 fatty acids Chemistry Cholesterol Sardine dyslipidemia high fat diet nutritional and metabolic diseases Cod liver oil medicine.disease biology.organism_classification 030220 oncology & carcinogenesis lipids (amino acids peptides and proteins) Full Communications Polyunsaturated fatty acid |
| Zdroj: | Journal of Medicinal Food |
| ISSN: | 1557-7600 1096-620X |
| Popis: | Dyslipidemia is one of the most important cardiovascular disease (CVD) risk factors. Polyunsaturated fatty acids (FAs), and especially omega-3 FAs, could significantly contribute to the management of dyslipidemia and the prevention of CVD. The anti-hyperlipidemic effect of selected fish oils (eel, sardine, trout, cod liver) was comparatively evaluated in a high fat diet (HFD)-fed mouse model. At the end of 30 days on the HFD, all animals were hyperlipidemic and were switched to a diet consisting of 90% standard rodent chow plus 10% of oil from eel, sardine, cod liver, or trout. At the end of 60 days on these diets, blood glucose, total blood cholesterol, triglycerides (TGs), and high density lipoprotein (HDL) were quantitated. All diets, except sardine and standard rodent chow, showed statistically significant decreases in blood glucose from day 30 to 90. Total blood cholesterol decreased in all diets except the HFD group, which was continued on this diet until the end of the study. Eel and cod liver oil diets showed significant decreases in TGs. All dietary groups showed a decrease in HDL, but only the trout and standard chow groups exhibited statistically significant decreases. The fish oils tested here for effects on hyperlipidemia vary in per cent of omega-3 FAs and omega-6/-3 FA ratios as determined by gas chromatography Overall, smoked eel was the best source of omega-3 FA, with a balance of omega-6 FA, that ameliorated HFD-induced mixed hyperlipidemia. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|