Laser Doppler flowmeter assessment of skin microcirculation in uremic patients on hemodialysis treatment
| Autor: | Marco Rossi, Guido Vagheggini, Adamasco Cupisti, G Tintori, G. Barsotti, A Fabbri, S Battini, E Morelli |
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| Rok vydání: | 1996 |
| Předmět: |
Adult
Male medicine.medical_specialty medicine.medical_treatment Blood Pressure Microcirculation Heart Rate Renal Dialysis medicine Laser-Doppler Flowmetry Humans Laser doppler flowmeter skin and connective tissue diseases Aged Skin Uremia Vascular disease business.industry Body Weight Middle Aged medicine.disease Surgery Malnutrition Regional Blood Flow Chronic renal failure Female sense organs Hemodialysis Complication business |
| Zdroj: | Nephron. 73(4) |
| ISSN: | 1660-8151 |
| Popis: | Vascular disease is frequent in uremics and may contribute to tissue malnutrition and damage. The aim of this study was to detect whether uremic patients show also changes of microcirculation and to evaluate the effects induced by hemodialysis (HD) session. Eleven uremics on HD (7 males, 4 females, aged 25-65 years) were studied; 11 healthy subjects, age- and sex-matched, served as controls. Skin microcirculatory basal flow (BF), maximal postischemic flow (PIF-max) and flow motion index (FMI) were determined at the upper limb contralateral to arteriovenous fistula, by means of a laser Doppler flowmeter. The measurements were taken before, at 1 and 2 h after starting HD and 30 min after the end of HD. In uremics, FMI was lower than in controls (mean +/- SD: 15.2 +/- 13.6 vs. 29.1 +/- 7.4%; p0.005); just 1 h after the start of HD, a significant improvement (28.4 +/- 17.7%; p0.01) versus basal values was observed and it persisted throughout the HD session. No statistical correlation was observed between the changes of FMI and those of plasma levels of Na+, K+, HCO-3, urea, iPTH or rate of ultrafiltration. BF and PIF-max were similar in uremics and controls, and no changes were observed during HD. Our study shows that the physiological flow motion is reduced in the skin microcirculation of uremics on HD. This abnormality is rapidly corrected by HD. |
| Databáze: | OpenAIRE |
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