Plasma Kisspeptin Levels in Newborn Infants with Breast Enlargement
| Autor: | Abdullah Erdil, Atilla Cayir, Avni Kaya, Harun Polat, Hakan Doneray, Zerrin Orbak |
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| Rok vydání: | 2015 |
| Předmět: |
Male
medicine.medical_specialty Kisspeptin Endocrinology Diabetes and Metabolism Muscle hypertrophy Immunoenzyme Techniques Endocrinology newborn Internal medicine Breast enlargement Humans Medicine Precocious puberty Breast Prospective Studies skin and connective tissue diseases Prospective cohort study Kisspeptins business.industry breast enlargement Infant Newborn Hypertrophy Luteinizing Hormone medicine.disease Prolactin Pediatrics Perinatology and Child Health Female Original Article business Luteinizing hormone hormones hormone substitutes and hormone antagonists Hormone |
| Zdroj: | Journal of Clinical Research in Pediatric Endocrinology |
| ISSN: | 1308-5727 |
| DOI: | 10.4274/jcrpe.1994 |
| Popis: | Objective: Kisspeptin levels have been reported in children with premature thelarche, precocious puberty and adolescent gynecomastia, but there are no reports on kisspeptin levels in the neonatal period. This study aimed to investigate plasma kisspeptin hormone levels in newborns with and without breast enlargement. Methods: Plasma kisspeptin levels and other related biochemical variables were investigated in this prospective study conducted on 40 (20 girls and 20 boys) newborn infants with breast enlargement and on 40 healthy control infants (20 girls and 20 boys). Two-milliliter venous blood samples were taken in hemogram tubes with K2EDTA. Kisspeptin assays were performed using the enzyme-immunoassay method. Results: Mean plasma kisspeptin levels were 0.6±0.2 ng/mL in the study group and 0.5±0.2 ng/mL in the control group. Plasma kisspeptin concentrations were significantly higher in the study group (p=0.039) and also showed a correlation with serum prolactin levels (p=0.006). Significant correlations were also determined between plasma kisspeptin and luteinizing hormone concentrations (p=0.05, r=0.312). Conclusion: The findings of this study suggest that plasma kisspeptin and serum prolactin levels may be involved in the physiopathology of breast enlargement in newborns. |
| Databáze: | OpenAIRE |
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