Farnesoid X receptor immunolocalization in reproductive tissues of adult female rabbits
| Autor: | G Hernández-Aragón Laura, Estela Cuevas, Francisco Castelán, Maribel Méndez-Tepepa, Pablo Pacheco, Margarita Martínez-Gómez, Arely Anaya-Hernández |
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| Rok vydání: | 2014 |
| Předmět: |
endocrine system
medicine.medical_specialty animal structures Histology Uterus Receptors Cytoplasmic and Nuclear Ovary Oviducts Biology Urethra Internal medicine medicine Animals Aromatase urogenital system Lipid metabolism Epithelial Cells Cell Biology General Medicine Immunohistochemistry medicine.anatomical_structure Endocrinology Organ Specificity Vagina biology.protein Oviduct Farnesoid X receptor Female Rabbits Corpus luteum |
| Zdroj: | Acta histochemica. 116(6) |
| ISSN: | 1618-0372 |
| Popis: | Farnesoid X receptor (FXR) has been involved in lipid metabolism, cell proliferation, apoptosis, and aromatase expression, as well as in the steroid synthesis and signaling. Considering that these events occur in reproductive tissues in females, the aim of the present study was to determine the immunolocalization of FXR in the ovary, oviduct, uterus, and vagina of rabbits. Rabbits were sacrificed and their reproductive tissues were excised and histologically processed. Immunohistochemistry for FXR was done and reproductive tissues were photographed. FXR immunoreactivity was found in all types of ovarian follicles, ovarian stroma, and corpus luteum of virgin and pregnant rabbits. Also, oviductal and vaginal epithelium of virgins, as well as the oviductal smooth muscle, showed anti-FXR immunoreactivity. The uterine epithelium and musculature of virgins had scarce anti-FXR immunoreactivity. Although the role of FXR in female reproductive tissues is still not known, it is possible to consider various functions related to the reproductive tissue. |
| Databáze: | OpenAIRE |
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