Antidepressant-like effect of pioglitazone in the forced swimming test in mice: The role of PPAR-gamma receptor and nitric oxide pathway
| Autor: | Mehrak Javadi-Paydar, Mohammad Salehi Sadaghiani, Yashar Yousefzadeh Fard, Ahmad Reza Dehpour, Mohammad Hadi Gharedaghi |
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| Rok vydání: | 2011 |
| Předmět: |
Male
medicine.medical_specialty Arginine Nitric Oxide Synthase Type II Peroxisome proliferator-activated receptor Motor Activity Pharmacology Nitric Oxide Guanidines Nitric oxide Mice Behavioral Neuroscience chemistry.chemical_compound Internal medicine medicine Animals Hypoglycemic Agents Anilides Enzyme Inhibitors Receptor Swimming chemistry.chemical_classification Dose-Response Relationship Drug Pioglitazone Antagonist Antidepressive Agents PPAR gamma Dose–response relationship NG-Nitroarginine Methyl Ester Endocrinology chemistry Thiazolidinediones human activities medicine.drug Behavioural despair test |
| Zdroj: | Behavioural Brain Research. 224:336-343 |
| ISSN: | 0166-4328 |
| Popis: | In this study, the potential antidepressant-like effects of pioglitazone and the possible involvement of peroxisome proliferator-activated receptor gamma (PPARγ) and nitric oxide system in antidepressant effects of pioglitazone were determined using forced swimming test (FST) in mice. Method After assessment of locomotor activity in open-field test, mice were forced to swim individually and the immobility time of the last 4 min was evaluated. Pioglitazone was administered orally with doses (5, 10, 20 and 30 mg/kg) 2 and 4 h before FST. To assess the involvement of PPARγ in the possible antidepressant effect of pioglitazone, GW9662, a PPARγ antagonist (2 mg/kg) was administered before pioglitazone (20 mg/kg). For determination of possible role of nitric oxide pathway in this effect, a non-specific NOS inhibitor, Nω-nitro- l -arginine methyl ester ( l -NAME, 10 mg/kg, i.p.), a specific iNOS inhibitor, aminoguanidine (50 mg/kg, i.p.), or a NO precursor, l -arginine (750 mg/kg, i.p.) was co-administered with pioglitazone, either 2 or 4 h before FST. Results The immobility time significantly decreased after pioglitazone administration (20 and 30 mg/kg). GW-9662 significantly reversed antidepressant effect of pioglitazone administered 2 and 4 h prior to FST. Co-administration of non-effective doses of pioglitazone and l -NAME revealed antidepressant-like effect in FST; while, co-administration of non-effective doses of aminoguanidine and pioglitazone did not affect the immobility time. l -Arginine also reversed the antidepressant-like effect of pioglitazone. Conclusion The antidepressant-like effect of pioglitazone on mice in the FST is mediated at least in part through PPARγ receptors and nitric oxide pathway. |
| Databáze: | OpenAIRE |
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