Adenosine A1 receptors mediate local anti-nociceptive effects of acupuncture
| Autor: | Nanna Goldman, Michael Chen, Takumi Fujita, Qiwu Xu, Weiguo Peng, Wei Liu, Tina K Jensen, Yong Pei, Fushun Wang, Xiaoning Han, Jiang-Fan Chen, Jurgen Schnermann, Takahiro Takano, Lane Bekar, Kim Tieu, Maiken Nedergaard |
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| Rok vydání: | 2010 |
| Předmět: |
Agonist
Adenosine medicine.drug_class Pain Pharmacology Article Statistics Nonparametric Mice Sciatica Adenosine A1 receptor Nucleotidases Acupuncture medicine Animals Pain Management Acupuncture Analgesia Anti nociceptive Receptor chemistry.chemical_classification Afferent Pathways Analysis of Variance business.industry General Neuroscience Receptors Purinergic P1 Peripheral Nervous System Diseases Disease Models Animal Enzyme chemistry business Adenosine metabolism medicine.drug |
| Zdroj: | Nature Neuroscience. 13:883-888 |
| ISSN: | 1546-1726 1097-6256 |
| Popis: | Acupuncture is an invasive procedure commonly used to relieve pain. Acupuncture is practiced worldwide, despite difficulties in reconciling its principles with evidence-based medicine. We found that adenosine, a neuromodulator with anti-nociceptive properties, was released during acupuncture in mice and that its anti-nociceptive actions required adenosine A1 receptor expression. Direct injection of an adenosine A1 receptor agonist replicated the analgesic effect of acupuncture. Inhibition of enzymes involved in adenosine degradation potentiated the acupuncture-elicited increase in adenosine, as well as its anti-nociceptive effect. These observations indicate that adenosine mediates the effects of acupuncture and that interfering with adenosine metabolism may prolong the clinical benefit of acupuncture. |
| Databáze: | OpenAIRE |
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