Coating of indomethacin-loaded embolic microspheres for a successful embolization therapy
Autor: | Jean-Claude Chaumeil, Faten Madani |
---|---|
Rok vydání: | 2008 |
Předmět: |
Materials science
Scanning electron microscope Stereochemistry Polymers Indomethacin Pharmaceutical Science Bioengineering engineering.material chemistry.chemical_compound Colloid and Surface Chemistry Adsorption Coating Polylactic Acid-Polyglycolic Acid Copolymer Technology Pharmaceutical Lactic Acid Physical and Theoretical Chemistry Microparticle chemistry.chemical_classification Coacervate Organic Chemistry Polymer Embolization Therapeutic Microspheres PLGA chemistry Solubility engineering Liberation Mathematics Polyglycolic Acid Nuclear chemistry |
Zdroj: | Journal of microencapsulation. 25(2) |
ISSN: | 0265-2048 |
Popis: | Indomethacin-loaded dietheylaminoethyl trisacryl microspheres (DEAE-MS), originally designed for therapeutic embolization, were encapsulated using two methods: coacervation and solvent evaporation/extraction. This encapsulation was achieved using a biocompatible polymer, the PLGA 50 : 50, and aimed to control the release of the anti-inflammatory non-steroidal drug (AINSD) in the occluded vessel. PLGA degradation study showed that it had an erosion half-life of approximately 35 days. Scanning electron microscopy (SEM) photographs showed that microcapsules (MC) prepared by coacervation had a wrinkled surface while those prepared using solvent-removal process showed non-porous, smooth surface, those of originally DEAE-MS showed a macro-porous, rough surface. The mean diameters were 61 microm for naked DEAE-MS vs. 71 microm and 65 microm for MC prepared by coacervation and solvent evaporation/extraction method, respectively. In vitro release study of indomethacin adsorbed onto MS indicated that drug release from MC was controlled by a diffusion process. Indomethacin diffusivity from MC was much lower than its free diffusivity from MS (mean 14.5 and 10.5 times lower for formulations prepared by coacervation and solvent evaporation/extraction method, respectively). This indicates that efficient indomethacin concentrations could be maintained over much longer time-periods in the embolized region, which is assumed to be beneficial in inhibiting normally occurring inflammatory reaction and the subsequent revascularization; responsible for treatment failure when definitive occlusion is required. |
Databáze: | OpenAIRE |
Externí odkaz: | |
Nepřihlášeným uživatelům se plný text nezobrazuje | K zobrazení výsledku je třeba se přihlásit. |