Chronic reserpine treatment on adrenergic neuronal and receptor function in the isolated perfused mesenteric blood vessels of the dog
| Autor: | Joseph P. Buckley, H.Richard Adams, David E. Clarke |
|---|---|
| Rok vydání: | 1970 |
| Předmět: |
Male
medicine.medical_specialty Reserpine Time Factors Sensory Receptor Cells Adrenergic Sympathetic nerve Stimulation Pharmacology Norepinephrine (medication) Norepinephrine Dogs Mesenteric Veins Internal medicine medicine Animals Receptor Adrenergic Agent Vascular tissue business.industry Electric Stimulation Intestines Endocrinology Female business medicine.drug |
| Zdroj: | European journal of pharmacology. 12(3) |
| ISSN: | 0014-2999 |
| Popis: | Chronic low dosage reserpine treatment significantly depressed the frequency-response curve to sympathetic nerve stimulation in the isolated perfused dog mesenteric and intestinal blood vessels. This neuronal depression was reversed by norepinephrine, indicating that chronic reserpine dosage fails to produce a drastic impairment of adrenergic nerve function. The dose-response curve to injected norepinephrine was not significantly altered, thus supersensitivity to norepinephrine following chronic reserpine treatment is not a common phenomenon in all vascular tissue. The pharmacological interaction of certain adrenergic agents with sympathetic neuronal and receptor mechanism appeared unaltered by reserpine. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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