The A-allele of the FTO Gene rs9939609 Polymorphism Is Associated With Decreased Proportion of Slow Oxidative Muscle Fibers and Over-represented in Heavier Athletes
| Autor: | Daniil V. Popov, Sofya A. Khabibova, Ildus I. Ahmetov, Evgeny A. Lysenko, Ekaterina V. Lyubaeva, João Paulo Limongi França Guilherme, Elena S. Kostryukova, Tatiana F. Vepkhvadze, Edward V. Generozov, Emiliya S. Egorova, Vadim M. Govorun, Ekaterina Semenova, Oleg V. Borisov, Antonio Herbert Lancha Junior, Elena A. Ospanova, Andrey K. Larin, Nickolay A. Kulemin, Egor M. Lednev, Alexander V. Pavlenko |
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| Rok vydání: | 2019 |
| Předmět: |
Adult
Male medicine.medical_specialty Genotype Alpha-Ketoglutarate-Dependent Dioxygenase FTO Physical Therapy Sports Therapy and Rehabilitation 030204 cardiovascular system & hematology Polymorphism Single Nucleotide FTO gene Russia Cohort Studies Young Adult 03 medical and health sciences 0302 clinical medicine Polymorphism (computer science) Internal medicine medicine Humans Orthopedics and Sports Medicine Muscle Strength Muscle fibre Allele Alleles biology business.industry Athletes Body Weight 030229 sport sciences General Medicine Odds ratio biology.organism_classification Oxidative Stress Muscle Fibers Slow-Twitch Phenotype Endocrinology Cohort Female business Brazil Sports |
| Zdroj: | Journal of Strength and Conditioning Research. 33:691-700 |
| ISSN: | 1064-8011 |
| DOI: | 10.1519/jsc.0000000000003032 |
| Popis: | Guilherme, JPLF, Egorova, ES, Semenova, EA, Kostryukova, ES, Kulemin, NA, Borisov, OV, Khabibova, SA, Larin, AK, Ospanova, EA, Pavlenko, AV, Lyubaeva, EV, Popov, DV, Lysenko, EA, Vepkhvadze, TF, Lednev, EM, Govorun, VM, Generozov, EV, Ahmetov, II, and Lancha Junior, AH. The A-allele of the FTO gene rs9939609 polymorphism is associated with decreased proportion of slow oxidative muscle fibers and over-represented in heavier athletes. J Strength Cond Res 33(3): 691-700, 2019-The purpose of this study was to explore the frequency of the FTO TA (rs9939609) polymorphism in elite athletes from 2 cohorts (Brazil and Russia), as well as to find a relationship between FTO genotypes and muscle fiber composition. A total of 677 athletes and 652 nonathletes were evaluated in the Brazilian cohort, whereas a total of 920 athletes and 754 nonathletes were evaluated in the Russian cohort. It was found a trend for a lower frequency of A/A genotype in long-distance athletes compared with nonathletes (odds ratio [OR]: 0.65; p = 0.054). By contrast, it was found an increased frequency of the A-allele in Russian power athletes. The presence of the T/A + A/A genotypes rather than T/T increased the OR of being a Russian power athlete compared with matched nonathletes (OR: 1.45; p = 0.002). Different from that observed in combat sports athletes of lighter weight categories, the A-allele was also over-represented in combat sports athletes of heavier weight categories. The presence of the T/A + A/A genotypes rather than T/T increased the OR of being a combat sports athlete of heavier weight categories compared with nonathletes (OR: 1.79; p = 0.018). Regarding the muscle fibers, we found that carriers of the A/A genotype had less slow-twitch muscle fibers than T-allele carriers (p = 0.029). In conclusion, the A/A genotype of the FTO TA polymorphism is under-represented in athletes more reliant on a lean phenotype and associated with decreased proportion of slow-twitch muscle fibers, while is over-represented in strength and heavier athletes. |
| Databáze: | OpenAIRE |
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