Organization of the axon initial segment: Actin like a fence
| Autor: | Matthew N. Rasband, Yu-Mei Huang |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
Tissue membrane Membrane Proteins Cell Biology Biology Superresolution Axon initial segment Models Biological Fence (mathematics) Actins Cell biology Diffusion 03 medical and health sciences 030104 developmental biology 0302 clinical medicine Membrane medicine.anatomical_structure Membrane protein medicine Commentary Axon Spotlight 030217 neurology & neurosurgery Actin Axon Initial Segment |
| Zdroj: | The Journal of Cell Biology |
| ISSN: | 1540-8140 0021-9525 |
| Popis: | Huang and Rasband discuss Albrecht et al.’s new model for the axon initial segment’s diffusion barrier. What prevents the movement of membrane molecules between axonal and somatodendritic domains is unclear. In this issue, Albrecht et. al. (2016. J. Cell Biol. http://dx.doi.org/10.1083/jcb.201603108) demonstrate via high-speed single-particle tracking and superresolution microscopy that lipid-anchored molecules in the axon initial segment are confined to membrane domains separated by periodically spaced actin rings. |
| Databáze: | OpenAIRE |
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