Interaction between yeast mitochondrial and nuclear genomes: Null alleles of RTG genes affect resistance to the alkaloid lycorine in rho0 petites of Saccharomyces cerevisiae
| Autor: | Paola Pontieri, Luigi Del Giudice, Klaus Werner Wolf, Domenica Rita Massardo |
|---|---|
| Rok vydání: | 2005 |
| Předmět: |
Mitochondrial DNA
Saccharomyces cerevisiae Proteins Nuclear gene Saccharomyces cerevisiae Mitochondrion Biology DNA Mitochondrial Genome Fungal Proteins chemistry.chemical_compound Drug Resistance Fungal Gene Expression Regulation Fungal Genetics Cycloheximide DNA Fungal Gene Alleles Cell Nucleus Protein Synthesis Inhibitors Basic Helix-Loop-Helix Leucine Zipper Transcription Factors Intracellular Signaling Peptides and Proteins RNA Fungal General Medicine Lycorine biology.organism_classification Phenanthridines Glucose chemistry Mutation Amaryllidaceae Alkaloids Genome Fungal Cell Division Gene Deletion Signal Transduction Mitochondrial DNA replication |
| Zdroj: | Gene. 354:9-14 |
| ISSN: | 0378-1119 |
| DOI: | 10.1016/j.gene.2005.03.020 |
| Popis: | Some nuclear genes in Saccharomyces cerevisiae (S. cerevisiae) respond to signals from the mitochondria in a process called by Butow (Cell Death Differ. 9 (2002) 1043–1045) retrograde regulation. Expression of these genes is activated in cells lacking mitochondrial function by involvement of RTG1, RTG2 and RTG3 genes whose protein products bind to “R-boxes” in the promoter region; RTG2p is a cytoplasmic protein. Since S. cerevisiae rho0 strains, lacking the entire mitochondrial genome, are resistant to lycorine, an alkaloid extracted from Amaryllis plants, it could be hypothesized that in rho0 cells the dysfunctional mitochondrial status stimulates overexpression of nuclear genes very likely involved in both nuclear and mitochondrial DNA replication. In this report we show that the resistance of rho0 cells to lycorine is affected by the deletion of RTG genes. |
| Databáze: | OpenAIRE |
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