| Autor: |
Sibon, D., Bisig, B., Bonnet, C., Poullot, E., Bachy, E., Cavalieri, D., Fataccioli, V., Bregnard, C., Drieux, F., Bruneau, J., Lemonnier, F., Dupuy, A., Bossard, C., Parrens, M., Bouabdallah, K., Ketterer, N., Berthod, G., Cairoli, A., Damaj, G., Tournilhac, O., Jais, J.P., Gaulard, P., De Leval, L. |
| Rok vydání: |
2022 |
| Předmět: |
|
| Zdroj: |
Haematologica |
| ISSN: |
1592-8721 |
| Popis: |
ALK-negative anaplastic large cell lymphoma (ALCL) comprises subgroups harboring rearrangements of DUSP22 (DUSP22- R) or TP63 (TP63-R). Two studies reported 90% and 40% 5-year overall survival (OS) rates in 21 and 12 DUSP22-R/TP63- not rearranged (NR) patients, respectively, making the prognostic impact of DUSP22-R unclear. Here, 104 newly diagnosed ALK-negative ALCL patients (including 37 from first-line clinical trials) from the LYSA TENOMIC database were analyzed by break-apart fluorescence in situ hybridization assays for DUSP22-R and TP63-R. There were 47/104 (45%) DUSP22-R and 2/93 (2%) TP63-R cases, including one DUSP22-R/TP63-R case. DUSP22-R tumors more frequently showed CD3 expression (62% vs. 35%, P=0.01), and less commonly a cytotoxic phenotype (27% vs. 82%; P |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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