Inoculation of mares and very young foals with EHV-1 glycoproteins D and B reduces virus shedding following respiratory challenge with EHV-1
| Autor: | Sharanne Raidal, J. M. Whalley, J. E. Wellington, C.E. Foote, G. Pecenpetelovska |
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| Rok vydání: | 2006 |
| Předmět: |
animal diseases
Immunology Equine herpesvirus 1 Enzyme-Linked Immunosorbent Assay Herpesvirus Vaccines Antibodies Viral Polymerase Chain Reaction Virus Viral Envelope Proteins Pregnancy Animals Horses Respiratory system Viral shedding General Veterinary biology Inoculation Herpesviridae Infections biology.organism_classification Virology Recombinant Proteins Virus Shedding Vaccination Nasal Mucosa Animals Newborn DNA Viral biology.protein Herd Female Horse Diseases Immunization Antibody Herpesvirus 1 Equid |
| Zdroj: | Veterinary immunology and immunopathology. 111(1-2) |
| ISSN: | 0165-2427 |
| Popis: | We have previously demonstrated that intramuscular inoculation of EHV-1 glycoprotein D (gD) and glycoprotein B (gB) produced by a recombinant baculovirus and formulated with the adjuvant Iscomatrix™ elicited virus-neutralizing antibody and gD- and gB-specific ELISA antibody in adult horses. In this study, 14 mares and their very young foals were inoculated with a combination of baculovirus-expressed EHV-1 gD and EHV-1 gB (EHV-1 gDBr) and challenged with a respiratory strain of EHV-1. Following experimental challenge, inoculated mares and foals shed virus in nasal secretions on significantly fewer occasions compared to uninoculated mares and foals. Uninoculated foals born from inoculated mares were no more protected against experimental challenge than uninoculated foals born from uninoculated mares. The results suggest that it is indeed possible to induce partial protection in very young foals through vaccination, and while the inoculation did not prevent infection, it did reduce the frequency of viral shedding with the potential to thereby reduce the risk and prevalence of infection in a herd situation. |
| Databáze: | OpenAIRE |
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