Apolipoprotein E-epsilon 4 deficiency and cognitive function in hepatitis C virus-infected patients

Autor: Markus Gess, Mary M.E. Crossey, Karin Weissenborn, Hans Worthmann, Simon D. Taylor-Robinson, L. M. Lugo Iparraguirre, Matthew A. Wozniak, Milani Deb-Chatterji, Daniel M. Forton, Henning Pflugrad, Anita B. Tryc, Annemarie Goldbecker, Meike Dirks, Ruth F. Itzhaki
Přispěvatelé: Medical Research Council (MRC)
Jazyk: angličtina
Rok vydání: 2015
Předmět:
Male
0301 basic medicine
Apolipoprotein E
Virus replication
Apolipoprotein E4
Hepacivirus
Pathogenesis
Neuropsychological Tests
medicine.disease_cause
E Epsilon-4
Liver disease
Cognition
Gene Frequency
Neuroinflammation
Surveys and Questionnaires
Medicine
Blood-brain-barrier
Attention
Glial activation
Magnetic-resonance-spectroscopy
Hepatic encephalopathy
Allele
neurodegeneration
Neurodegenerative Diseases
Hepatitis C
Middle Aged
Memory
Short-Term
Infectious Diseases
Liver
Medical Microbiology
Female
Life Sciences & Biomedicine
Adult
Hepatitis C virus encephalopathy
Hepatitis C virus
Clinical Sciences
03 medical and health sciences
Virology
Humans
Cognitive Dysfunction
Allele frequency
Alleles
Cerebral lipoprotein metabolism
Aged
Apoe
Science & Technology
Hepatology
Gastroenterology & Hepatology
Mood Disorders
business.industry
HIV
Hepatitis C
Chronic
medicine.disease
030104 developmental biology
Mood disorders
Hepatic Encephalopathy
Immunology
Quality of Life
business
Liver-disease
Popis: Hepatitis C virus (HCV) causes not only liver damage in certain patients but can also lead to neuropsychiatric symptoms. Previous studies have shown that the type 4 allele of the gene for apolipoprotein E (APOE) is strongly protective against HCV-induced damage in liver. In this study, we have investigated the possibility that APOE genotype is involved in the action of HCV in brain. One hundred HCV-infected patients with mild liver disease underwent a neurological examination and a comprehensive psychometric testing of attention and memory function. In addition, patients completed questionnaires for the assessment of fatigue, health-related quality of life and mood disturbances. Apolipoprotein E gene genotyping was carried out on saliva using buccal swabs. The APOE-ε4 allele frequency was significantly lower in patients with an impairment of working memory, compared to those with a normal working memory test result (P = 0.003). A lower APOE-ε4 allele frequency was also observed in patients with definitely altered attention ability (P = 0.008), but here, the P-value missed the level of significance after application of the Bonferroni correction. Our data suggest that the APOE-ε4 allele is protective against attention deficit and especially against poor working memory in HCV-infected subjects with mild liver disease. Considering the role of apolipoprotein E in the life cycle of the virus, the findings shed interesting new light upon possible pathomechanisms behind the development of neuropsychiatric symptoms in hepatitis C infection.
Databáze: OpenAIRE
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