Partial Clinical Remission Reduces Lipid-Based Cardiovascular Risk in Adult Patients With Type 1 Diabetes

Autor: Austin F Lee, Benjamin U. Nwosu, Layana Al-Halbouni, Gabrielle Jasmin, Sadichchha Parajuli, Krish Khatri
Rok vydání: 2021
Předmět:
Adult
Male
medicine.medical_specialty
endocrine system diseases
Adolescent
type 1 diabetes
Cvd risk
Endocrinology
Diabetes and Metabolism
Type 2 diabetes
Gastroenterology
Diseases of the endocrine glands. Clinical endocrinology
Young Adult
Endocrinology
Internal medicine
adults
medicine
Humans
honeymoon phase
Original Research
Aged
Dyslipidemias
Retrospective Studies
Type 1 diabetes
Adult patients
Atherosclerotic cardiovascular disease
business.industry
dyslipidemia
Remission Induction
nutritional and metabolic diseases
Middle Aged
RC648-665
Atherosclerosis
Prognosis
medicine.disease
Lipids
Obesity
cardiovascular disease risk
Diabetes Mellitus
Type 1
Cardiovascular Diseases
Heart Disease Risk Factors
Case-Control Studies
Cohort
Female
type 2 diabetes
business
Biomarkers
Dyslipidemia
partial clinical remission
Follow-Up Studies
Zdroj: Frontiers in Endocrinology
Frontiers in Endocrinology, Vol 12 (2021)
ISSN: 1664-2392
DOI: 10.3389/fendo.2021.705565
Popis: ImportanceRisk factors for atherosclerotic cardiovascular disease (ASCVD) are well established in type 2 diabetes (T2D), but not in type 1 diabetes (T1D). The impact of partial clinical remission (PR) on short-term ASCVD risk in T1D is unclear.AimTo investigate the impact of PR on the earliest ASCVD risk phenotype in adult T1D using factor analysis to compare the lipid phenotypes of T1D, T2D and controls after stratifying the T1D cohort into remitters and non-remitters.Subjects and MethodsA study of 203 adults subjects consisting of 86 T2D subjects, and 77 T1D subjects stratified into remitters (n=49), and non-remitters (n=28). PR was defined as insulin-dose adjusted HbA1c of ≤9, and obesity as a BMI ≥30 kg/m2. Factor analysis was used to stratify the groups by ASCVD risk by factorizing seven lipid parameters (TC, LDL, HDL, non-HDL, TC/HDL, TG, TG/HDL) into 2 orthogonal factors (factor 1: TC*LDL; factor 2: HDL*TG) that explained 90% of the variance in the original seven parameters.ResultsThe analysis of individual lipid parameters showed that TC/HDL was similar between the controls and remitters (p=NS) but was significantly higher in the non-remitters compared to the remitters (p=0.026). TG/HDL was equally similar between the controls and remitters (p=NS) but was lower in the remitters compared to the non-remitters (p=0.007). TG was significantly lower in the remitters compared to T2D subjects (pversusnon-remitters (p=0.0003) but was similar between the controls and remitters (p=NS). Factor analysis showed that the means of factor 1 and factor 2 composite scores for dyslipidemia increased linearly from the controls, remitters, non-remitters to T2D, p value 0.0042 for factor 1, and ConclusionsPartial clinical remission of T1D is associated with a favorable early lipid phenotype which could translate to reduced long-term CVD risk in adults.
Databáze: OpenAIRE
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