Comparative evaluation of three capripoxvirus-vectored peste des petits ruminants vaccines
| Autor: | F. Fakri, Zhigao Bu, F. Ghzal, O. Fassi Fihri, Mehdi Elharrak, Weiye Chen, Zahra Bamouh, W. Baha, Khalid Omari Tadlaoui |
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| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
Sheep Diseases Poxviridae Infections Antibodies Viral Capripoxvirus Peste-des-petits-ruminants virus Comparative evaluation law.invention Viral Proteins 03 medical and health sciences Immunity law Virology Peste-des-Petits-Ruminants Animals Vector (molecular biology) Goat Diseases Sheep biology Goats Viral Vaccines Hemagglutinin biology.organism_classification Fusion protein Hemagglutinins 030104 developmental biology Recombinant DNA Viral Fusion Proteins |
| Zdroj: | Virology. 514:211-215 |
| ISSN: | 0042-6822 |
| DOI: | 10.1016/j.virol.2017.11.015 |
| Popis: | Sheep and goat pox (SGP) with peste des petits ruminants (PPR) are transboundary viral diseases of small ruminants that cause huge economic losses. Recombinant vaccines that can protect from both infections have been reported as a promising solution for the future. SGP was used as a vector to express two structural proteins hemagglutinin or the fusion protein of PPRV. We compared immunity conferred by recombinant capripoxvirus vaccines expressing H or F or both HF. Safety and efficacy were evaluated in goats and sheep. Two vaccine doses were tested in sheep, 104.5TCDI50 in 1 ml dose was retained for the further experiment. Results showed that the recombinant HF confers an earlier and stronger immunity against both SGP and PPR. This recombinant vaccine protect also against the disease in exposed and unexposed sheep. The potential Differentiating Infected from Vaccinated Animals of recombinant vaccines is of great advantage in any eradication program. |
| Databáze: | OpenAIRE |
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