Immunohistological insight into the correlation between cardiac and lingual musculature in chronic chagas disease

Autor:	Marcela Beghini, Douglas Reis Abdalla, Janainna Grazielle Pacheco Olegario, Taíssa Cássia de Souza Furtado, Juliana Barbosa de Faria, Denise Bertulucci Rocha Rodrigues, Ruchele Dias Nogueira, Sanívia Aparecida de Lima Pereira
Jazyk:	angličtina
Rok vydání:	2022
Předmět:	Chagas disease T. cruzi Enfermedad de Chagas Citocinas Língua Lengua Doença de Chagas Citoquinas Tongue parasitic diseases cardiovascular system General Earth and Planetary Sciences Cytokines General Environmental Science
Zdroj:	Research, Society and Development; Vol. 11 No. 5; e58211528156 Research, Society and Development; Vol. 11 Núm. 5; e58211528156 Research, Society and Development; v. 11 n. 5; e58211528156 Research, Society and Development Universidade Federal de Itajubá (UNIFEI) instacron:UNIFEI
ISSN:	2525-3409
Popis:	Aim: To assess and compare the inflammatory infiltrate, area of muscle cells, microvessel density (MVD) and expression of cytokines in the myocardium (MM) and lingual (LM) musculature between chagasic and non chagasic individuals. Methods: Fragments of MM and LM from autopsied chronic chagasic (CC) (n=18) and non chagasic individuals (n=24) were histologically processed for histochemical and immunohistochemical evaluation. Was assessed the MVD by CD31 and quantification of immune cells infiltrated in MM and LM, and also expression of IL-1, IL-10 and TGF- β1. Results: There were higher intensity of inflammation and larger area of muscle cells in the myocardium and tongue of chagasic compared to non-chagasic individuals (p
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d958b3c24f370059dd3b94419cc063db https://rsdjournal.org/index.php/rsd/article/view/28156 Zobrazit plný text záznamu