Steroidogenesis inhibitors. 1. Adrenal inhibitory and interceptive activity of trilostane and related compounds

Autor:	A. J. Anzalone, Gordon O. Potts, H. C. Neumann, Malcolm R. Bell, Robert G. Christiansen, John E. Creange, H. P. Schane, U. J. Salvador
Rok vydání:	1984
Předmět:	medicine.medical_specialty 3-Hydroxysteroid Dehydrogenases Magnetic Resonance Spectroscopy Spectrophotometry Infrared medicine.medical_treatment Trilostane Inhibitory postsynaptic potential Steroid Adrenocorticotropic Hormone Pregnancy Internal medicine Drug Discovery Adrenal Glands medicine Animals Pseudopregnancy Progesterone Abortifacient Agents Chemistry Abortifacient Agents Steroidal Biological activity Dihydrotestosterone Methylation Macaca mulatta Rats Endocrinology Female sexual function Molecular Medicine Female Corticosterone medicine.drug
Zdroj:	Journal of medicinal chemistry. 27(7)
ISSN:	0022-2623
Popis:	Several methylated derivatives of trilostane were prepared. Methylation of C-4 or C-4 and C-17 changes this relatively selective adrenal inhibitor to compounds with increased ovarian/placental inhibitory activity with decreased adrenal inhibitory activity.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d9588fb490e6c2d5d8119c6339a6c5fa https://pubmed.ncbi.nlm.nih.gov/6330362 Zobrazit plný text záznamu