Placental progonadotropin-releasing hormone (Pro-GnRH) in the rhesus monkey
| Autor: | Theresa M. Duello, Timothy A. Boyle |
|---|---|
| Rok vydání: | 1997 |
| Předmět: |
endocrine system
medicine.medical_specialty Arginine Placenta Endocrinology Diabetes and Metabolism Molecular Sequence Data Peptide Biology Polymerase Chain Reaction Human chorionic gonadotropin Gonadotropin-Releasing Hormone Endocrinology Pregnancy Internal medicine medicine Animals Humans Amino Acid Sequence Cloning Molecular Protein Precursors chemistry.chemical_classification Messenger RNA Base Sequence Trophoblast Macaca mulatta Amino acid medicine.anatomical_structure chemistry Female hormones hormone substitutes and hormone antagonists Hormone |
| Zdroj: | Endocrine. 6:21-24 |
| ISSN: | 1559-0100 0969-711X |
| DOI: | 10.1007/bf02738797 |
| Popis: | Gonadotropin-releasing hormone (GnRH) has been shown to play a role in the regulation of human chorionic gonadotropin (hCG) secretion by the human placenta. Molecular studies have demonstrated that human placental trophoblast cells synthesize a progonadotropin-releasing hormone (pro-GnRH) identical to its human hypothalamic counterpart. However, far less is known about nonhuman primates. To determine whether pro-GnRH exists in the rhesus placenta, pro-GnRH mRNA was cloned, sequenced, and shown to be 97.6% homologous to its human placental counterpart. A single base difference (base 1167) in the domain encoding GnRH results in the same amino acid, arginine, in position 8, whereas four base differences (bases 1200, 1253, 1268, 1292) in the domain encoding GnRH-associated peptide (GAP) result in four different amino acids in positions 19, 37, 42, and 50. The absence of a basic amino acid in position 50 suggests the rhesus sequence may be cleaved to yield GAP peptides different from the human placenta. Thus, these data justify the use of mammalian GnRH in studies of rhesus placental function, but indicate the need to investigate the roles unique GAP peptides may play in placental/uterine function. |
| Databáze: | OpenAIRE |
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