| Autor: |
Dong-Qing Ye, Yin-Guang Fan, Li-Jun Deng, Xin-Yu Fang, Jun Wu, Qing-Ru Li, Yan-Mei Mao, Rui-Xue Leng |
| Rok vydání: |
2022 |
| Předmět: |
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| Zdroj: |
Current pharmaceutical design. 28(27) |
| ISSN: |
1873-4286 |
| Popis: |
Background: N6-methyladenosine (m6A) modification is widespread in eukaryotic mRNA, regulated by m6A demethylase, AlkB homolog 5 (ALKBH5). However, the role of m6A in systemic lupus erythematosus (SLE) is still obscure. We explored ALKBH5 expression in SLE patients and its effects on T cells. Methods: 100 SLE patients and 110 healthy controls were recruited to investigate the expression of ALKBH5 in peripheral blood mononuclear cells (PBMCs). An additional 32 SLE patients and 32 health controls were enrolled to explore the expression of ALKBH5 in T cells. Then we explored the function of ALKBH5 in T cells by lentivirus. Results: The expressions of ALKBH5 were downregulated in both PBMCs and T cells in SLE patients (all P Conclusion: Conclusion: ALKBH5 expression is downregulated in SLE patients and could affect the apoptosis and proliferation of T cells, but the exact mechanism still needs to be further explored. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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