Characterization of seizures (ILAE 1981 and 2017 classifications) and their response to treatment in a cohort of patients with glial tumors: A prospective single center study
| Autor: | Ignacio Casas Parera, Paola Castellanos Oropeza, Fernando Quintans, Alejandra Báez, María Cecilia Sánchez Retamar, María Alejandra González Roffo |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: |
Pediatrics
medicine.medical_specialty business.industry Central nervous system Disease Single Center medicine.disease Response to treatment 03 medical and health sciences Epilepsy 0302 clinical medicine medicine.anatomical_structure Neurology Cohort medicine Etiology Effective treatment Original Article 030212 general & internal medicine business 030217 neurology & neurosurgery |
| Zdroj: | eNeurologicalSci |
| ISSN: | 2405-6502 |
| Popis: | Epilepsy is a common symptom in patients with primary central nervous system (CNS) tumors. Seizures are reported in 15–95% of patients with brain tumors, depending on the type of tumor [1]. Seizures are the presenting symptom in 15–50% of patients with gliomas, and up to 75% will have at least one seizure at some point in the disease course [2]. The recognition and classification of epileptic seizures and providing effective treatment are essential to preserve the quality of life of patients with glial tumors. In a previous study, we found that 63% of patients with glial tumors experienced seizures at some point in the disease course. Sixty two percent of seizures were focal onset, while 38% were generalized onset seizures [3]. However, considering the tumor etiology of seizures, we were unable to verify the results. Therefore, the goal of this study was to present the results of a larger cohort of patients with primary glial tumors and epilepsy based on a more rigorous examination approach. The primary objectives of this study were to classify and quantify epileptic seizures as a symptom of onset or later in the course of the disease and the correlation between ILAE 1981 and 2017 classifications [5,6]. The secondary objectives were to quantify: 1) the cases in which epileptic seizures were reclassified; 2) patients who received antiepileptic drugs (AEDs) as monotherapy; 3) patients whose antiepileptic treatment on admission was modified; and (4) patients whose seizures were controlled with the prescribed AEDs. |
| Databáze: | OpenAIRE |
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