Cuphea spp.: antichemotactic study for a potential anti-inflammatory drug
| Autor: | Betina M. Beltrame, Krissie D. Soares, Amélia T. Henriques, Miriam Anders Apel, Marí Castro Santos, Sérgio Augusto de Loreto Bordignon, Andreas Sebastian Loureiro Mendez |
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| Rok vydání: | 2020 |
| Předmět: |
Drug
Traditional medicine 010405 organic chemistry medicine.drug_class media_common.quotation_subject Organic Chemistry Plant Science Biology Antimicrobial biology.organism_classification 01 natural sciences Biochemistry Anti-inflammatory 0104 chemical sciences Analytical Chemistry Cuphea 010404 medicinal & biomolecular chemistry Genus medicine Lythraceae media_common |
| Zdroj: | Natural Product Research. 35:6058-6061 |
| ISSN: | 1478-6427 1478-6419 |
| Popis: | Cuphea genus (Lythraceae) popularly known in Brazil as “sete-sangrias”, it’s described as antimicrobial, anti-inflammatory, diuretic and antihypertensive mainly. Investigating the chemotactic ability plays an important role in the identification of new anti-inflammatory agents. Thus, this research aims to assay the antichemotactic activity of hydroethanolic extracts of C. calophylla, C. carthagenensis, C. glutinosa, and C. racemosa as well as the compounds miquelianin and myricitrin. The antichemotactic activity of the hydroethanolic extracts, miquelianin, and myricitrin were assayed at concentrations 0.001 to 10 µg/mL in the lipopolysaccharide-induced chemotaxis on rat polymorphonuclear neutrophils. All the assayed samples displayed antichemotactic activity with reduction of the neutrophil migration in the range of 4.46-100%, and an IC50 value in the range of 0.30-1.24 µg/mL. Thus, this study demonstrates that the extracts hydroethanolic of Cuphea species, miquelianin, and myricitrin display a significant antichemotactic activity. Therefore, in future studies, extracts from Cuphea spp. could be used as anti-inflammatory drugs. |
| Databáze: | OpenAIRE |
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