Dermal nerves in human diabetic subjects
| Autor: | Peter C. Johnson, Susan C. Doll |
|---|---|
| Rok vydání: | 1984 |
| Předmět: |
Adult
Male Diabetic neuropathy Endocrinology Diabetes and Metabolism Sural nerve Perineurial Cell Basement Membrane Myelin Diabetic Neuropathies Biopsy Internal Medicine Medicine Humans Aged Skin Basement membrane Neurons integumentary system medicine.diagnostic_test business.industry Anatomy Middle Aged medicine.disease Microscopy Electron medicine.anatomical_structure Peripheral nervous system Skin biopsy Female business |
| Zdroj: | Diabetes. 33(3) |
| ISSN: | 0012-1797 |
| Popis: | The lack of a nerve tissue source that is easily, safely, and repeatedly available has been a major impediment to the study of human diabetic neuropathy. In this study dermal nerves from skin, obtained at biopsy and autopsy from the lower leg and at autopsy from the mid-abdomen, were subjected to quantitative electron microscopy to assess for diabetic perineurial cell basement membrane thickening, a change previously reported in sural nerve. A highly significant degree of perineurial cell basement membrane thickening was found in the diabetic subjects. Other structures in dermal nerves, such as axons, myelin, Schwann cells, and their organelles are also amenable to quantitative ultrastructural study. Skin biopsy is a way to obtain samples of peripheral nervous system tissue safely and repeatedly for the study of diabetic neuropathy. |
| Databáze: | OpenAIRE |
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