Hypercholesterolemia Blunts Forearm Vasorelaxation and Enhances the Pressor Response During Acute Systemic Hypoxia
| Autor: | T L R Martinez, Ana Paula Marte Chacra, Raul D. Santos, Eduardo M. Krieger, José Eduardo Krieger, José Augusto Soares Barreto-Filho, Grazia Maria Guerra-Riccio, Heno Ferreira Lopes, Fernanda Marciano Consolim-Colombo, Sandra H. Teixeira |
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| Rok vydání: | 2003 |
| Předmět: |
Adult
Male medicine.medical_specialty Adolescent Endothelium Hypercholesterolemia Blood Pressure Pressoreceptors Vasodilation Forearm Internal medicine medicine Humans Respiratory system Endothelial dysfunction Hypoxia business.industry Carbon Dioxide Middle Aged Hypoxia (medical) medicine.disease medicine.anatomical_structure Blood pressure Endocrinology Regional Blood Flow Acute Disease Vascular resistance Female medicine.symptom Cardiology and Cardiovascular Medicine business |
| Zdroj: | Arteriosclerosis, Thrombosis, and Vascular Biology. 23:1660-1666 |
| ISSN: | 1524-4636 1079-5642 |
| DOI: | 10.1161/01.atv.0000089471.61037.21 |
| Popis: | Objective— During hypoxia, active substances released by the endothelium play a key role in the cardiovascular and respiratory responses elicited to optimize oxygen delivery. As hypercholesterolemia is a major cause of endothelial dysfunction, it may interfere with these responses. Methods and Results— We studied cardiovascular and ventilatory responses to acute systemic hypoxia in 14 patients with hypercholesterolemia (HC) and 13 control (CO) subjects. Oxygen saturation decreased similarly in both groups. Diastolic blood pressure increased only in the HC group ( P =0.0002) and, despite systolic blood pressure increases both in the HC group, 140±4 (95% confidence interval [CI],131 to 149 mm Hg) to 154±4 mm Hg (95% CI,145 to 164 mm Hg), and in the CO group, 133±3 (95% CI,126 to 140 mm Hg) to 140±4 mm Hg (95% CI,132 to 148 mm Hg), the HC group showed an enhanced pressor response ( P =0.03, group comparison). Both groups had increased forearm blood flow, but the decrease in forearm vascular resistance in the CO group, 40±5 (95% CI, 30 to 51 UR) to 31±4 UR (95% CI,23 to 39 UR) ( P =0.0001) was not seen in the HC group, 29±3 (95% CI, 22 to 37 UR) to 26±3 UR (95% CI, 20 to 33 UR), ( P =0.03, group comparison). Conclusions— Hypercholesterolemic patients demonstrate a hyperreactive pressor response and absence of forearm vasodilation during acute systemic hypoxia. |
| Databáze: | OpenAIRE |
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