Components of the metabolic syndrome as predictors of cardiovascular disease and type 2 diabetes in middle-aged Japanese men
| Autor: | Mitsuharu Okamoto, Wenjuan Li, Kenji Suzuki, Noriyuki Nakanishi, Yoshio Matsuo, Hiroshi Yoshida, Kokoro Shirai, Kozo Tatara, Hideki Fukuda, Toshio Takatorige |
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| Rok vydání: | 2003 |
| Předmět: |
Adult
Male medicine.medical_specialty Endocrinology Diabetes and Metabolism Coronary Disease Type 2 diabetes Cohort Studies Endocrinology Japan Predictive Value of Tests Risk Factors Diabetes mellitus Internal medicine Internal Medicine medicine Humans Metabolic Syndrome business.industry Incidence (epidemiology) Smoking General Medicine Middle Aged medicine.disease Impaired fasting glucose Obesity Stroke Diabetes Mellitus Type 2 Relative risk Metabolic syndrome business Dyslipidemia Diabetic Angiopathies |
| Zdroj: | Diabetes research and clinical practice. 64(1) |
| ISSN: | 0168-8227 |
| Popis: | To determine whether the clustered features of the metabolic syndrome precede the 7 year incidence of cardiovascular disease (CVD) and type 2 diabetes, we examined 6182 Japanese male office workers aged 35-59 years without any history of CVD. The 5588 subjects without type 2 diabetes also constituted the nondiabetic cohort, and were re-examined over seven successive years. Components of the metabolic syndrome included glycemic disorder (type 2 diabetes for the risk of CVD and impaired fasting glucose for the risk of type 2 diabetes), systemic obesity, hypertension, dyslipidemia, proteinuria, and elevated white blood cell (WBC) count. After controlling for age, family history of diabetes, alcohol intake, and cigarette smoking, the multivariate-adjusted relative risk of incidence of CVD compared with absence of components was 3.18, 3.48, 12.55, and 14.15 (P for trend0.001), for the presence of 1,2,3, andor =4 components, respectively. The corresponding relative risks of incidence of type 2 diabetes were 1.92, 4.36, 6.44, and 15.08 (P for trend0.001). In both non-smokers and current smokers, the multivariate-adjusted relative risks of incidence of CVD and type 2 diabetes increased as the number of components increased (P for trend0.001 for all). Our findings indicate that clustered features of the metabolic syndrome are closely associated with development of CVD and type 2 diabetes in middle-aged Japanese. |
| Databáze: | OpenAIRE |
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