FOXP2 expression and gray matter density in the male brains of patients with schizophrenia

Autor: J. Javier Meana, Gracián García-Martí, Noelia Sebastiá-Ortega, María Dolores Moltó, Julio Sanjuán, Javier Gilabert-Juan, Josep Maria Haro, Luis Martí-Bonmatí, Javier González-Fernández, Roberto Sanz-Requena, Juan Nacher, Xochitl Helga Castro-Martínez
Rok vydání: 2020
Předmět:
Male
Candidate gene
Sistema nerviós central Malalties
FOXP2
Cognitive Neuroscience
Physiology
Biology
03 medical and health sciences
Behavioral Neuroscience
Cellular and Molecular Neuroscience
Magnetic resonance imaging
0302 clinical medicine
male
Neuroimaging
expression
Genetic variation
medicine
magnetic resonance imaging
Humans
Radiology
Nuclear Medicine and imaging
Gray Matter
Prefrontal cortex
Original Research
Cerebral Cortex
medicine.diagnostic_test
language lateralization
severe speech
Brain morphometry
syndrome scale panss
association
Neuropsychology
Brain
Forkhead Transcription Factors
gray matter
disorder
030227 psychiatry
schizophrenia
Psychiatry and Mental health
Neurology
Schizophrenia
Esquizofrènia
genetic-variation
Neurology (clinical)
polymorphisms
030217 neurology & neurosurgery
Zdroj: Brain Imaging and Behavior
Addi: Archivo Digital para la Docencia y la Investigación
Universidad del País Vasco
Sanjuán Arias, Julio Castro-Martínez, Xochitl Helga García Martí, Gracián González-Fernández, Javier Sanz-Requena, Roberto Haro, Josep María Meana, J. Javier Martí Bonmatí, Luis Nácher Roselló, Juan Salvador Sebastiá Ortega, Noelia Gilabert Juan, Javier Moltó Ruiz, María Dolores 2020 FOXP2 expression and gray matter density in the male brains of patients with schizophrenia Brain Imaging And Behavior
RODERIC. Repositorio Institucional de la Universitat de Valéncia
instname
Addi. Archivo Digital para la Docencia y la Investigación
RODERIC: Repositorio Institucional de la Universitat de Valéncia
ISSN: 1931-7565
1931-7557
DOI: 10.1007/s11682-020-00339-x
Popis: Common genetic variants ofFOXP2may contribute to schizophrenia vulnerability, but controversial results have been reported for this proposal. Here we evaluated the potential impact of the commonFOXP2rs2396753 polymorphism in schizophrenia. It was previously reported to be part of a risk haplotype for this disease and to have significant effects on gray matter concentration in the patients. We undertook the first examination into whether rs2396753 affects the brain expression ofFOXP2and a replication study of earlier neuroimaging findings of the influence of this genetic variant on brain structure.FOXP2expression levels were measured in postmortem prefrontal cortex samples of 84 male subjects (48 patients and 36 controls) from the CIBERSAM Brain and the Stanley Foundation Array Collections. High-resolution anatomical magnetic resonance imaging was performed on 79 male subjects (61 patients, 18 controls) using optimized voxel-based morphometry. We found differences inFOXP2expression and brain morphometry depending on the rs2396753, relating lowFOXP2mRNA levels with reduction of gray matter density. We detected an interaction between rs2396753 and the clinical groups, showing that heterozygous patients for this polymorphism have gray matter density decrease and lowFOXP2expression comparing with the heterozygous controls. This study shows the importance of independent replication of neuroimaging genetic studies ofFOXP2as a candidate gene in schizophrenia. Furthermore, our results suggest that theFOXP2rs2396753 affects mRNA levels, thus providing new knowledge about its significance as a potential susceptibility polymorphism in schizophrenia. The genomic DNA and RNA samples corresponding to the Array Collection were donated by the Stanley Medical Research Institute Brain Collection courtesy of Drs. Michael B. Knable, E. Fuller Torrey, Maree J. Webster, and Robert H. Yolken. The postmortem human brain tissues were donated by the Brain Collections of the Spanish National Network for Research in Mental Health CIBERSAM. The authors also thank the collaboration of the staff members of the Basque Institute of Legal Medicine, Sant Joan de Deu Foundation and the Psychiatry Unit of Hospital Clinico of Valencia. XHC was supported by a postdoctoral fellowship from CONACYT, Mexico; NSO and JGJ were recipients of research contracts from CIBERSAM, Spain.
Databáze: OpenAIRE
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