Pregenerative medicine: developmental paradigms in the biology of cardiovascular regeneration
| Autor: | B. Alexander Yi, Kenneth R. Chien, Oliver Wernet |
|---|---|
| Rok vydání: | 2010 |
| Předmět: |
ved/biology.organism_classification_rank.species
Physiology Review Biology Regenerative Medicine Regenerative medicine Myoblasts Animals Humans Regeneration Progenitor cell Model organism Homeodomain Proteins Heart development ved/biology Stem Cells Regeneration (biology) Heart General Medicine Holy Grail Muscle regeneration Homeobox Protein Nkx-2.5 Stem cell T-Box Domain Proteins Neuroscience Transcription Factors |
| Zdroj: | Journal of Clinical Investigation. 120:20-28 |
| ISSN: | 0021-9738 |
| DOI: | 10.1172/jci40820 |
| Popis: | The ability to create new functional cardiomyocytes is the holy grail of cardiac regenerative medicine. From studies using model organisms, new insights into the fundamental pathways that drive heart muscle regeneration have begun to arise as well as a growing knowledge of the distinct families of multipotent cardiovascular progenitors that generate diverse lineages during heart development. In this Review, we highlight this intersection of the "pregenerative" biology of heart progenitor cells and heart regeneration and discuss the longer term challenges and opportunities in moving toward a therapeutic goal of regenerative cardiovascular medicine. |
| Databáze: | OpenAIRE |
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