Neoadjuvant and Adjuvant Treatment with Denosumab in Aggressive Giant-cell Tumor of Bone in the Proximal Fibula: a Case Report
| Autor: | Petya M Tsenova, Svetoslav A. Slavchev, Violeta V Marinova, Georgi P. Georgiev, Kircho Patrikov |
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| Rok vydání: | 2018 |
| Předmět: |
medicine.medical_specialty
medicine.medical_treatment lcsh:Medicine Nuclear factor kappa b 03 medical and health sciences 0302 clinical medicine Proximal fibula medicine neoadjuvant therapy Neoadjuvant therapy RANK ligand biology business.industry lcsh:R denosumab General Medicine medicine.disease Osteolytic lesion osteoclasts Denosumab 030220 oncology & carcinogenesis biology.protein 030211 gastroenterology & hepatology Radiology Antibody business giant cell tumor of bone Adjuvant Giant-cell tumor of bone medicine.drug |
| Zdroj: | Folia Medica, Vol 60, Iss 4, Pp 637-640 (2018) |
| ISSN: | 1314-2143 |
| DOI: | 10.2478/folmed-2018-0067 |
| Popis: | Giant cell tumor of bone is a histologically benign but locally aggressive osteolytic lesion, capable of spreading ‘benign’ metastases mainly to the lungs. Since its description as a separate entity, surgery has been the mainstay of treatment. Recently, target therapy has been introduced using denosumab – an inhibitor antibody for the receptor activator of nuclear factor kappa B ligand with dramatic eff ect on the natural course of the tumor. Herein, we report a rare case of an aggressive stage 3 giant cell tumor of bone of the proximal fibula that was successfully downstaged using neoadjuvant denosumab treatment and then treated by surgical excision followed by adjuvant target therapy. The clinical characteristics and treatment modalities of giant cell tumor of bone, the indications for target therapy, therapy response, and histological changes are also briefly discussed. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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