Cross-neutralisation of Australian brown snake, taipan and death adder venoms by monovalent antibodies
| Autor: | Geoffrey K. Isbister, Tammy Jacoby, Jessica Hagan, Wayne C. Hodgson, Jennifer Schneider, Margaret A. O'Leary, Kearney Nichols, Kathleen Davern |
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| Rok vydání: | 2009 |
| Předmět: |
Antivenom
Enzyme-Linked Immunosorbent Assay Pharmacology Cross Reactions complex mixtures Pseudonaja textilis Oxyuranus scutellatus Animals Snake antivenom Elapidae Blood Coagulation Neurons integumentary system General Veterinary General Immunology and Microbiology biology Antivenins Venoms digestive oral and skin physiology Public Health Environmental and Occupational Health Australia biology.organism_classification Antibodies Neutralizing Taipan Brown snake Infectious Diseases Snake venom Immunoglobulin G Immunology Molecular Medicine Acanthophis Rabbits |
| Zdroj: | Vaccine. 28(3) |
| ISSN: | 1873-2518 |
| Popis: | An understanding of the cross-neutralisation of snake venoms by antibodies is important for snake antivenom development. We investigated the cross-neutralisation of brown snake (Pseudonaja textilis) venom, taipan (Oxyuranus scutellatus) venom and death adder (Acanthophis antarcticus) with commercial antivenoms and monovalent anti-snake IgG, using enzyme immunoassays, in vitro clotting and neurotoxicity assays. Each commercial antivenom bound all three venoms, and neutralised clotting activity of brown snake and taipan venoms and neurotoxicity of death adder venom. The 'in-house' monovalent anti-snake venom IgG raised against procoagulant brown snake and taipan venoms, did not neutralise the neurotoxic effects of death adder venom. However, they did cross-neutralise the procoagulant effects of both procoagulant venoms. This supports the idea of developing antivenoms against groups of snake toxins rather than individual snake venoms. |
| Databáze: | OpenAIRE |
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