Correlation between clinical findings and eosinophil/neutrophil ratio in patients with nasal polyps

Autor: S. Hancer Tecimer, Fikret Kasapoglu, Oğuz Basut, Omer Afsin Ozmen, Hamdi Hakan Coskun, Uygar Levent Demir
Přispěvatelé: Uludağ Üniversitesi/Tıp Fakültesi/Kulak Burun Boğaz ve Baş ve Cerrahi Anabilim Dalı., Tecimer, S. Hancer, Kasapoğlu, Fikret, Demir, Uygar Levent, Özmen, Ömer Afşin, Çoşkun, Hakan H., Basut, Oğuz İbrahim, A-1452-2019, AAI-3877-2021
Rok vydání: 2014
Předmět:
Male
Turkey
Neutrophils
chinese
Eosinophil
Procedures
Gastroenterology
Neutrophilic
Recurrence
Eosinophilic
Paranasal Sinuses
Prevalence
Pathology
Nasal polyps
Features
Chronic rhinosinusitis with nasal polyp
Rhinitis
medicine.diagnostic_test
Paranasal sinus
Neutrophil
General Medicine
Chronic Rhinosinusitis
Sinuses
Asthma and Nasal Polyps
respiratory system
Prognosis
Retrospective study
medicine.anatomical_structure
Treatment Outcome
Female
Neurosurgery
Human
Adult
medicine.medical_specialty
Cells
Population
Pathophysiology
Nasal Polyps
Internal medicine
Eosinophilia
Computer assisted tomography
otorhinolaryngologic diseases
medicine
Humans
Clinical significance
Sinusitis
Retrospective Studies
Clinical characteristics
Eosinophilic chronic rhinosinusitis
business.industry
Retrospective cohort study
Endoscopy
medicine.disease
Eosinophils
Otorhinolaryngology
Chronic Disease
business
Tomography
X-Ray Computed
Complication
Zdroj: European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery. 272(4)
ISSN: 1434-4726
Popis: Chronic rhinosinusitis with nasal polyps (CRSwNP) is a frequent disease which can be classified as eosinophilic or neutrophilic based on dominant inflammatory cell type at tissue. The aim of this study was to evaluate the clinical relevance of classifying nasal polyps as eosinophilic or neutrophilic on treatment outcomes. The study was conducted with 40 patients who underwent either surgical or medical treatment with the diagnosis of CRSwNP. The patients were classified into two groups for further assessment up to eosinophil intensity at polyp tissue. All patients were examined by nasal endoscopy and paranasal computed tomography (CT). Before treatment, subjective symptom score, nasal endoscopy score, and CT score were measured. Subsequently, they were reevaluated by similar diagnostic tests after either medical or surgical treatment at sixth month. The preoperative subjective symptom score, endoscopy score, and paranasal CT score were compared between chronic rhinosinusitis (CRS) with eosinophilic nasal polyps (E-NP) (CRSwE-NP) group and CRS with neutrophilic nasal polyps group and there was no difference between the two groups (p = 0.369, p = 0.310 and p = 0.494 respectively). Although after treatment in both groups symptom score and endoscopy score were significantly improved but not the CT score, we found no difference in between the groups at sixth month. In most of the previous studies, patients with CRSwE-NP were assumed to have poor prognosis and high recurrence rate despite surgical or medical treatment. However, we did not find any association between eosinophilic or neutrophilic nature of nasal polyp tissue and disease severity.
Databáze: OpenAIRE
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