Patient-reported outcomes in systemic AL amyloidosis with functional assessment of cancer therapy-general (FACT-G) and patient-reported outcomes measurement information system-global health (PROMIS-GH) in a real-world population

Autor:	Jacqulyn Tomer, Navneet S. Majhail, Rajshekhar Chakraborty, Beth Faiman, Jason Valent, Christy J. Samaras, Lisa Rybicki
Rok vydání:	2019
Předmět:	Adult Male Cancer Research Patient-Reported Outcomes Measurement Information System medicine.medical_specialty Cancer therapy Global Health Article 03 medical and health sciences 0302 clinical medicine Quality of life (healthcare) Surveys and Questionnaires AL amyloidosis medicine Global health Humans In patient Immunoglobulin Light-chain Amyloidosis Patient Reported Outcome Measures Intensive care medicine Aged Retrospective Studies Aged 80 and over business.industry Hematology World population Middle Aged medicine.disease Prognosis United States Survival Rate Oncology 030220 oncology & carcinogenesis Quality of Life Observational study Female business 030215 immunology Follow-Up Studies
Zdroj:	Leuk Lymphoma
ISSN:	1029-2403
Popis:	We performed an observational study on health-related quality of life (HRQoL) in patients with AL amyloidosis diagnosed between 2012 and 2017 at our institution. A total of 81 patients were included, with a median age of 64 years. The mean FACT-G (Functional assessment of Cancer Therapy-General) total score at baseline (≤2 months from diagnosis) was 74 (±15), compared to a normative score of 80 (±18) in the general U.S. population. Significant HRQoL deficit was noted only in the functional well-being (FWB) domain of FACT-G. Using PROMIS-GH (Patient-Reported Outcomes Measurement Information System-Global Health) at baseline (n=18), a greater deficit was noted in the global physical health (GPH) compared to global mental health (GMH) domain. FACT-FWB and PROMIS-GPH domain scores were able to significantly discriminate between revised Mayo stages. Development and validation of an amyloid-specific PRO instrument incorporating specific domains of interest is urgently needed to pursue patient-centered drug development.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d94a022d66f967e501349eb9b21875f3 https://pubmed.ncbi.nlm.nih.gov/31272258 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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