The relationship between vascular endothelial growth factor (VEGF) and amnestic mild cognitive impairment among older adults living with HIV
Autor: | Jessica L. Montoya, Laura M Campbell, Jennifer E. Iudicello, Erin E. Sundermann, David J. Moore, Vanessa Serrano, Robert K. Heaton, Scott Letendre |
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Rok vydání: | 2021 |
Předmět: |
Oncology
Vascular Endothelial Growth Factor A Male Aging VEGF receptors Vascular Endothelial Growth Factor C Vascular Endothelial Growth Factor D Neuropsychological Tests Logistic regression chemistry.chemical_compound Cognition Medicine Cognitive decline Cognitive impairment biology Vascular Endothelial Growth Factors Middle Aged VEGF Vascular endothelial growth factor AIDS Mental Health Infectious Diseases Neurology Medical Microbiology 6.1 Pharmaceuticals HIV/AIDS Female medicine.medical_specialty Clinical Sciences behavioral disciplines and activities Cellular and Molecular Neuroscience Acquired immunodeficiency syndrome (AIDS) Internal medicine Virology mental disorders Humans Cognitive Dysfunction Placenta Growth Factor business.industry Prevention Neurosciences Evaluation of treatments and therapeutic interventions HIV medicine.disease PIGF chemistry biology.protein Amnestic mild cognitive impairment Neurology (clinical) business |
Zdroj: | Journal of neurovirology, vol 27, iss 6 |
Popis: | Older people with HIV (PWH) experience increased risk of age-related neurodegenerative disorders and cognitive decline, such as amnestic mild cognitive impairment (aMCI). The objective of this study was to examine the relationship between aMCI and plasma VEGF biomarkers among older PWH. Data were collected at a university-based research center from 2011 to 2013. Participants were 67 antiretroviral therapy-treated, virally suppressed PWH. Participants completed comprehensive neurobehavioral and neuromedical evaluations. aMCI status was determined using adapted Jak/Bondi criteria, classifying participants as aMCI + if their performance was > 1 SD below the normative mean on at least two of four memory assessments. VEGF family plasma biomarkers (i.e., VEGF, VEGF-C, VEGF-D, and PIGF) were measured by immunoassay. Logistic regression models were conducted to determine whether VEGF biomarkers were associated with aMCI status. Participants were mostly non-Hispanic white (79%) men (85%) with a mean age of 57.7 years. Eighteen (26.9%) participants met criteria for aMCI. Among potential covariates, only antidepressant drug use differed by aMCI status, and was included as a covariate. VEGF-D was significantly lower in the aMCI + group compared to the aMCI − group. No other VEGF levels (VEGF, VEGF-C, PIGF) differed by aMCI classification (ps > .05). In a sample of antiretroviral therapy-treated, virally suppressed PWH, lower levels of VEGF-D were associated with aMCI status. Longitudinal analyses in a larger and more diverse sample are needed to support VEGF-D as a putative biological marker of aMCI in HIV. |
Databáze: | OpenAIRE |
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