Advances in Injectable In Situ-Forming Hydrogels for Intratumoral Treatment

Autor:	Jae-Ho Kim, Sangdun Choi, Hee Eun Kim, Gi Ru Shin, Moon Suk Kim
Rok vydání:	2021
Předmět:	Chemotherapy business.industry medicine.medical_treatment intratumoral injection Pharmaceutical Science Cancer Review medicine.disease Bioavailability Cancer treatment RS1-441 Pharmacy and materia medica Self-healing hydrogels Drug delivery medicine Cancer research cancer injectable in situ-forming hydrogel business anticancer effect
Zdroj:	Pharmaceutics Pharmaceutics, Vol 13, Iss 1953, p 1953 (2021)
ISSN:	1999-4923
DOI:	10.3390/pharmaceutics13111953
Popis:	Chemotherapy has been linked to a variety of severe side effects, and the bioavailability of current chemotherapeutic agents is generally low, which decreases their effectiveness. Therefore, there is an ongoing effort to develop drug delivery systems to increase the bioavailability of these agents and minimize their side effects. Among these, intratumoral injections using in situ-forming hydrogels can improve drugs’ bioavailability and minimize drugs’ accumulation in non-target organs or tissues. This review describes different types of injectable in situ-forming hydrogels and their intratumoral injection for cancer treatment, after which we discuss the antitumor effects of intratumoral injection of drug-loaded hydrogels. This review concludes with perspectives on the future applicability of, and challenges for, the adoption of this drug delivery technology.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d946466ade7a4bf0e768206aaae05899 https://doi.org/10.3390/pharmaceutics13111953 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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