Intraglomerular Immune Cell Infiltration and Complement 3 Deposits in Membranoproliferative Glomerulonephritis Type I: A Serial-Biopsy Study of 25 Cases
| Autor: | Keishi Abe, Takashi Furuta, Hiroshi Sato, Tetsuya Ootaka, Jun Soma, Takao Saito, Jin Seino |
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| Rok vydání: | 1994 |
| Předmět: |
Adult
Male Pathology medicine.medical_specialty Cellular immunity Adolescent Glomerulonephritis Membranoproliferative Biopsy Kidney Glomerulus Pathogenesis Membranoproliferative glomerulonephritis Leukocytes Humans Medicine Child biology medicine.diagnostic_test business.industry Macrophages Antibodies Monoclonal Glomerulonephritis Complement C3 medicine.disease Nephrology Humoral immunity biology.protein Mesangial proliferative glomerulonephritis Female Antibody business |
| Zdroj: | American Journal of Kidney Diseases. 23:365-373 |
| ISSN: | 0272-6386 |
| DOI: | 10.1016/s0272-6386(12)80998-x |
| Popis: | We examined chronological changes in intraglomerular immune cell infiltration in comparison to the changes in glomerular complement 3 (C3) deposits (C3-D) and serum complement levels in 25 patients with membranoproliferative glomerulonephritis (MPGN) type I. These patients were divided into the following two groups: group A (n = 13), cases in which there were fewer intraglomerular C3-D at the second biopsy (2nd-Bx) than at the first biopsy (1st-Bx); and group B (n = 12), those in which the amount of C3-D at the 2nd-Bx was greater than or equal to that at the 1st-Bx. At the 1st-Bx, monocytes (Mo)/macrophages (M phi) and total leukocytes (TLC) were the predominant cell types in both groups, whereas T cells were less marked. At the 2nd-Bx, only group A showed a significant decrease in the number of either Mo/M phi (P0.01), TLC (P0.01), pan-T cells (P0.01), or intraglomerular nuclei per glomerular cross-section ([NIN] P0.01). In group B, there was a positive correlation between the number of intraglomerular pan-T cells (CD3-positive cells) and M phi (CD68-positive cells, P0.05 at the 1st-Bx and P0.01 at the 2nd-Bx), but not in group A. An improvement in light-microscopic findings and a significant decrease of urinary protein excretion (P0.05) at the 2nd-Bx was observed only in group A. Hypocomplementemia (hypo-C) was found in 12 of 13 cases of group A and in eight of 12 cases of group B at the 1st-Bx. Hypo-C in group A was not found at the 2nd-Bx. On the other hand, in group B, hypo-C was still observed in the eight cases and was found in one additional case at the 2nd-Bx.(ABSTRACT TRUNCATED AT 250 WORDS) |
| Databáze: | OpenAIRE |
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