| Autor: |
Mona M, Hassona, Tamer, Fouad, Merhan Osama, Helmi, Heba Samy Mohammed, Ghanem, Heba E Abd, Elrhman, Eman, Abdelsameea |
| Rok vydání: |
2021 |
| Předmět: |
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| Zdroj: |
Clinical and Experimental Hepatology. 7:370-376 |
| ISSN: |
2392-1099 |
| DOI: |
10.5114/ceh.2021.111490 |
| Popis: |
Despite achieving a high cure rate of chronic hepatitis C nowadays, treatment failure remains a major concern and host genetic polymorphism could have a possible relation. The aim was to evaluate the role of chemokine receptor CXCR6 gene polymorphism in treatment response to direct acting antivirals (DAAs) in chronic hepatitis C virus (HCV) patients.We investigated the chemokine receptor CXCR6 gene single nucleotide polymorphism rs2234358 in three groups. Responder and non-responder groups (each comprising 50 naïve patients) and a control group of 50 apparently healthy individuals were studied.Genotype distribution revealed a significant difference (CXCR6 gene (rs2234358) polymorphism could have a potential role in the virological treatment response with a protective effect of the T allele. This could explain the higher treatment success rate of Egyptian HCV patients. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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