Depiction of dentatorubrothalamic tract fibers in patients with Parkinson’s disease and multiple sclerosis in deep brain stimulation

Autor: Georges Dooms, Frank Hertel, Anisa Hana, Hans Boecher-Schwarz, Ardian Hana
Rok vydání: 2016
Předmět:
Male
Pathology
medicine.medical_specialty
Multiple Sclerosis
Deep brain stimulation
Internal capsule
Red nucleus
Deep Brain Stimulation
medicine.medical_treatment
Thalamus
Pyramidal Tracts
Neurosurgery
Neurodegenerative disease
General Biochemistry
Genetics and Molecular Biology
030218 nuclear medicine & medical imaging
Stereotaxic Techniques
White matter
03 medical and health sciences
0302 clinical medicine
medicine
Humans
Aged
Medicine(all)
Brain Mapping
White matter tract
Biochemistry
Genetics and Molecular Biology(all)
business.industry
Motor Cortex
Parkinson Disease
General Medicine
Anatomy
Middle Aged
Axons
Diffusion Tensor Imaging
medicine.anatomical_structure
Cerebellar Nuclei
Corticospinal tract
Female
Brainstem
business
030217 neurology & neurosurgery
Research Article
Motor cortex
Zdroj: BMC Research Notes
ISSN: 1756-0500
Popis: Background We wanted to depict fibers of the dentatorubrothalamic tract in patients with Parkinson’s disease and multiple sclerosis in order to use this knowledge for clinical routine and to show its relation to the corticospinal tract for deep brain stimulation. Fibers of these white matter tracts were depicted between February 2014 and February 2015 in nine patients of all ages. There were seven men and two women. The mean age was 60 years. We used a 3DT1 sequence for the navigation. Additional scanning time was less than 9 min. Both tracts were portrayed in all patients. Results We were able to successfully portray these white matter tracts in all patients. We visualized the medial and lateral parts of the corticospinal tract by using a region of interest which covered the whole motor cortex. Furthermore we segmented the motor cortex. The fibers ran from this area of the brain through the internal capsule and they could be followed until their entry in the brainstem. The dentatorubrothalamic tract was smaller than the corticospinal tract. It was situated medio-posteriorly of the corticospinal tract. After decussation to the contralateral red nucleus it was localised next to the midline when it entered the motor cortex. From the thalamus on, it proceeds medially and posteriorly of the corticospinal tract further to the motor cortex. Depiction of the whole tract is essential for the differentiation of the dentatorubrothalamic tract with the corticospinal tract. Conclusions The depiction of the dentatorubrothalamic tract might be useful for neurosurgeons when deep brain stimulation is planned. Knowing its relation to other white matter tracts can help physicians like neurosurgeons or neurologists avoid side effects and deal with patients with DBS. The position of the electrode might be crucial for a satisfactory outcome.
Databáze: OpenAIRE
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