Effect of HLA on Hepatitis C Virus Clearance and Persistence in Anti-HCV-positive End-stage Renal Disease Patients
| Autor: | Serkan Ocal, Haldun Selçuk, Abdullah Emre Yildirim, Enver Akbas, Murat Korkmaz, Reskan Altun |
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| Jazyk: | angličtina |
| Rok vydání: | 2014 |
| Předmět: |
hepatitis C virus
Adult Male Turkey Hepatitis C virus Human leukocyte antigen Hepacivirus medicine.disease_cause Risk Assessment Statistics Nonparametric End stage renal disease viral persistence Cohort Studies End-stage renal disease Sex Factors Antigen HLA Antigens Predictive Value of Tests medicine Humans lcsh:RC799-869 Aged Retrospective Studies Chi-Square Distribution biology business.industry Incidence human leukocyte antigen genotyping Gastroenterology Age Factors Middle Aged Viral Load Prognosis Hepatitis C Transplantation Exact test Immunology biology.protein Kidney Failure Chronic lcsh:Diseases of the digestive system. Gastroenterology Original Article Female Antibody business CD8 viral clearance |
| Zdroj: | Saudi Journal of Gastroenterology : Official Journal of the Saudi Gastroenterology Association The Saudi Journal of Gastroenterology, Vol 20, Iss 3, Pp 175-181 (2014) |
| ISSN: | 1998-4049 1319-3767 |
| Popis: | Background/Aims: The efficacy of immune response against hepatitis C virus (HCV) is determined by human leukocyte antigen (HLA) molecules of the host which present HCV antigens to CD4 + and CD8 + T lymphocytes. In this study, we aimed to investigate the possible relationship between the frequencies of certain HLA class I-II alleles and the natural history of HCV in patients with end-stage renal disease (ESRD). Settings and Design: This is a retrospective cohort study conducted in a university hospital. Patients and Methods: The present study comprised 189 ESRD patients (candidates for renal transplantation) who had positive anti-HCV antibody test. The results concerning HCV and HLA status were gathered from patients′ files. The viral persistence was compared between the groups that were determined by HLA sub-typing. Statistical Analysis: Statistical evaluation was performed using Mann-Whitney U-test, Chi-square test, and Fisher′s exact test. Level of error was set at 0.05 for all statistical evaluations, and P values < 0.05 were considered statistically significant. Results: We found possible association between the course of HCV infection and specific HLA alleles. HLA class I CwFNx016 and HLA class II DRBFNx0110 alleles were observed more frequently in the viral clearance group (P < 0.05). The HLA class I BFNx0138 allele group was more prone to develop chronic hepatitis C (P < 0.01). Conclusions: These findings suggest that HLA class I CwFNx016 and HLA class II DRBFNx0110 alleles may be associated with immunological elimination of HCV in Turkish patients on hemodialysis. HLA sub-typing could help predict the prognosis of HCV infection. |
| Databáze: | OpenAIRE |
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