Calcium phosphate cements: Optimization toward biodegradability
Autor: | John A. Jansen, I. Lodoso-Torrecilla, J.J.J.P van den Beucken |
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Přispěvatelé: | Universitat Politècnica de Catalunya. Departament de Ciència i Enginyeria de Materials |
Rok vydání: | 2021 |
Předmět: |
Calcium Phosphates
Ceramics Bone Regeneration Materials science 0206 medical engineering Biomedical Engineering chemistry.chemical_element Biocompatible Materials 02 engineering and technology Calcium Enginyeria dels materials [Àrees temàtiques de la UPC] Biochemistry Bone cements Biomaterials macroporosity Degradation Time windows Materials Testing medicine Bone formation Tissue engineering Molecular Biology Macroporosity degradation Bone Cements General Medicine Biodegradation 021001 nanoscience & nanotechnology Bone defect 020601 biomedical engineering Calcium phosphate cements Reconstructive and regenerative medicine Radboud Institute for Molecular Life Sciences [Radboudumc 10] medicine.anatomical_structure chemistry Calcium phosphate Enginyeria de teixits Irregular bone Invasive surgery Ciments ossis 0210 nano-technology Fosfat de calci Biotechnology Biomedical engineering |
Zdroj: | ACTA BIOMATERIALIA r-FSJD. Repositorio Institucional de Producción Científica de la Fundació Sant Joan de Déu instname Acta Biomaterialia, 119, 1-12 UPCommons. Portal del coneixement obert de la UPC Universitat Politècnica de Catalunya (UPC) Acta Biomaterialia, 119, pp. 1-12 |
ISSN: | 1742-7061 |
Popis: | Contains fulltext : 229128.pdf (Publisher’s version ) (Open Access) Synthetic calcium phosphate (CaP) ceramics represent the most widely used biomaterials for bone regenerative treatments due to their biological performance that is characterized by bioactivity and osteoconductive properties. From a clinical perspective, injectable CaP cements (CPCs) are highly appealing, as CPCs can be applied using minimally invasive surgery and can be molded to optimally fill irregular bone defects. Such CPCs are prepared from a powder and a liquid component, which upon mixing form a paste that can be injected into a bone defect and hardens in situ within an appropriate clinical time window. However, a major drawback of CPCs is their poor degradability. Ideally, CPCs should degrade at a suitable pace to allow for concomitant new bone to form. To overcome this shortcoming, control over CPC degradation has been explored using multiple approaches that introduce macroporosity within CPCs. This strategy enables faster degradation of CPC by increasing the surface area available to interact with the biological surroundings, leading to accelerated new bone formation. For a comprehensive overview of the path to degradable CPCs, this review presents the experimental procedures followed for their development with specific emphasis on (bio)material properties and biological performance in pre-clinical bone defect models. |
Databáze: | OpenAIRE |
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