Progastrin: a potential predictive marker of liver metastasis in colorectal cancer
| Autor: | David A. Westwood, Christopher Christophi, Graham S. Baldwin, Oneel Patel, Arthur Shulkes |
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| Rok vydání: | 2017 |
| Předmět: |
Male
0301 basic medicine Oncology medicine.medical_specialty Colorectal cancer medicine.medical_treatment Adenocarcinoma Mouse model of colorectal and intestinal cancer Gastroenterology Metastasis 03 medical and health sciences 0302 clinical medicine Internal medicine Gastrins Biomarkers Tumor medicine Adjuvant therapy Humans Protein Precursors Neoadjuvant therapy Aged Neoplasm Staging Predictive marker business.industry Liver Neoplasms Cancer Middle Aged medicine.disease 030104 developmental biology 030220 oncology & carcinogenesis Female Colorectal Neoplasms business |
| Zdroj: | International Journal of Colorectal Disease. 32:1061-1064 |
| ISSN: | 1432-1262 0179-1958 |
| DOI: | 10.1007/s00384-017-2822-8 |
| Popis: | Staging of colorectal cancer often fails to discriminate outcomes of patients with morphologically similar tumours that exhibit different clinical behaviours. Data from several studies suggest that the gastrin family of growth factors potentiates colorectal cancer tumourigenesis. The aim of this study was to investigate whether progastrin expression may predict clinical outcome in colorectal cancer. Patients with colorectal adenocarcinoma of identical depth of invasion who had not received neoadjuvant therapy were included. The patients either had stage IIa disease with greater than 3-year disease-free survival without adjuvant therapy or stage IV disease with liver metastases on staging CT. Progastrin expression in tumour sections was scored with reference to the intensity and area of immunohistochemical staining. Progastrin expression by stage IV tumours was significantly greater than stage IIa tumours with mean progastrin immunopositivity scores of 2.1 ± 0.2 versus 0.5 ± 0.2, respectively (P |
| Databáze: | OpenAIRE |
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