Differential white matter involvement associated with distinct visuospatial deficits after right hemisphere stroke
| Autor: | Gordon L. Shulman, Kristi Zinn, Xin Hong, Maurizio Corbetta, Serguei V. Astafiev, Nicholas V. Metcalf, Alex R. Carter, Joshua S. Siegel, Jennifer Rengachary, Mark P. McAvoy |
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| Jazyk: | angličtina |
| Rok vydání: | 2017 |
| Předmět: |
Adult
Male Dissociation (neuropsychology) Visuospatial attention Cognitive Neuroscience Posterior parietal cortex Logistic regression Experimental and Cognitive Psychology Neuropsychological Tests Insular cortex 050105 experimental psychology Article Functional Laterality Lesion White matter Perceptual Disorders 03 medical and health sciences 0302 clinical medicine Hemispatial neglect medicine Reaction Time Humans 0501 psychology and cognitive sciences Attention Orientation Spatial Aged Aged 80 and over Lymphokines 05 social sciences Brain Stroke Neuropsychology and Physiological Psychology Middle Aged Visual field medicine.anatomical_structure Frontal lobe Space Perception Visual Perception Female medicine.symptom Psychology Neuroscience 030217 neurology & neurosurgery |
| Popis: | Visuospatial attention depends on the integration of multiple processes, and people with right hemisphere lesions after a stroke may exhibit severe or no visuospatial deficits. The anatomy of core components of visuospatial attention is an area of intense interest. Here we examine the relationship between the disruption of core components of attention and lesion distribution in a heterogeneous group (N = 70) of patients with right hemisphere strokes regardless of the presence of clinical neglect. Deficits of lateralized spatial orienting, measured as the difference in reaction times for responding to visual targets in the contralesional or ipsilesional visual field, and deficits in re-orienting attention, as measured by the difference in reaction times for invalidly versus validly cued targets, were measured using a computerized spatial orienting task. Both measures were related through logistic regression and a novel ridge regression method to anatomical damage measured with magnetic resonance imaging. While many regions were common to both deficit maps, a deficit in lateralized spatial orienting was more associated with lesions in the white matter underlying the posterior parietal cortex, and middle and inferior frontal gyri. A deficit in re-orienting of attention toward unattended locations was associated with lesions in the white matter of the posterior parietal cortex, insular cortex and less so with white matter involvement of the anterior frontal lobe. An hodological analysis also supports this partial dissociation between the white matter tracts that are damaged in lateralized spatial biases versus impaired re-orienting. Our results underscore that the integrity of fronto-parietal white matter tracts is crucial for visuospatial attention and that different attention components are mediated by partially distinct neuronal substrates. |
| Databáze: | OpenAIRE |
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