Starch/PCL composite nanofibers by co-axial electrospinning technique for biomedical applications
| Autor: | Sevil Yücel, Mehmet S. Eroglu, Zeynep Aydin Sinirlioglu, Oguzhan Gunduz, Nazmi Ekren, Faik N. Oktar, Baran Kömür, F. Bayrak, Olcay Guler |
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| Přispěvatelé: | Komur, B., Bayrak, F., Ekren, N., Eroglu, M. S., Oktar, F. N., Sinirlioglu, Z. A., Yucel, S., Guler, O., Gunduz, O. |
| Jazyk: | angličtina |
| Rok vydání: | 2017 |
| Předmět: |
Starch
Composite number Nanofibers Biocompatible Materials 02 engineering and technology SILVER NANOPARTICLES 01 natural sciences NANOCOMPOSITE BLENDS Mice chemistry.chemical_compound Electricity Nanotechnology Fiber Composite material EPSILON-CAPROLACTONE Radiological and Ultrasound Technology Viscosity food and beverages General Medicine 021001 nanoscience & nanotechnology Electrospinning lcsh:R855-855.5 PCL Wound dressing Polycaprolactone 0210 nano-technology BEHAVIOR FIBERS lcsh:Medical technology Materials science Cell Survival Polyesters Biomedical Engineering FABRICATION 010402 general chemistry Biomaterials Ultimate tensile strength Animals Radiology Nuclear Medicine and imaging Fourier transform infrared spectroscopy Mechanical Phenomena Wound Healing Research Electric Conductivity Nanofiber DEGRADATION 0104 chemical sciences chemistry NIH 3T3 Cells |
| Zdroj: | BioMedical Engineering BioMedical Engineering OnLine, Vol 16, Iss 1, Pp 1-13 (2017) |
| Popis: | Background In this study, starch and polycaprolactone (PCL), composite nanofibers were fabricated by co-axial needle electrospinning technique. Processing parameters such as polymer concentration, flow rate and voltage had a marked influence on the composite fiber diameter. Fourier transform infrared spectroscopy, scanning electron microscopy (SEM), mechanical and physical properties (such as density, viscosity and electrical conductivity) of the composite fibres were evaluated. Moreover, a cell culture test was performed in order to determine their cytotoxicity for wound dressing application. Results The effect of starch ratio in the solution on the properties and morphological structure of the fibers produced was presented. With lower starch concentration values, the fibers have greater ultimate tensile strength characteristic (mostly 4 and 5 wt%). According to SEM results, it can be figured out that the nanofibers fabricated have good spinnability and morphology. The mean diameter of the fibers is about 150 nm. According to results of cell culture study, the finding can be determined that the increase of starch in the fiber also increases the cell viability. Conclusions Composite nanofibers of starch/PCL have been prepared using a co-axial needle electrospinning technique. PCL was successfully encapsulated within starch. Fiber formation was observed for different ratio of starch. With several test, analysis and measurement performed, some important parameters such as quality and effectuality of each fiber obtained for wound dressing applications were discussed in detail. |
| Databáze: | OpenAIRE |
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