Failure to Replicate Influence of GRIK4 and GNB3 Polymorphisms on Treatment Outcome in Major Depression
| Autor: | Joseph Zohar, Alessandro Serretti, Julien Mendlewicz, Carlos Forray, M. Fink, Sylvie Linotte, Raffaella Calati, Lenore Snyder, Irina Antonijevic, Siegfried Kasper, Diana De Ronchi, Ursula F. Bailer, Concetta Crisafulli, Isabelle Massat, Yves Lecrubier, Alberto Chiesa, Joseph Bollen, Daniel Souery |
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| Přispěvatelé: | Serretti, A, Chiesa, A, Crisafulli, C, Massat, I, Linotte, S, Calati, R, Kasper, S, Bailer, U, Lecrubier, Y, Fink, M, Antonijevic, I, Forray, C, Snyder, L, Bollen, J, Zohar, J, De Ronchi, D, Souery, D, Mendlewicz, J, Serretti A., Chiesa A., Crisafulli C., Massat I., Linotte S., Calati R., Kasper S., Bailer U., Lecrubier Y., Fink M., Antonijevic I., Forray C., Snyder L., Bollen J., Zohar J., De Ronchi D., Souery D., Mendlewicz J. |
| Jazyk: | angličtina |
| Rok vydání: | 2012 |
| Předmět: |
Adult
Male Oncology medicine.medical_specialty Candidate gene Genotype Treatment outcome GNB3 GRIK4 Gene Frequency Receptors Kainic Acid Internal medicine medicine Humans Genetic Association Studies Biological Psychiatry Depression (differential diagnoses) Aged Genetic association MAJOR DEPRESSIVE DISORDER Depressive Disorder Major Polymorphism Genetic biology Replicate Middle Aged medicine.disease Heterotrimeric GTP-Binding Proteins Antidepressive Agents Psychiatry and Mental health Treatment Outcome Neuropsychology and Physiological Psychology Major depressive disorder GRIK4 GNB3 biology.protein Regression Analysis Major depressive disorder Female Psychology Clinical psychology |
| Popis: | In the present study, we aimed to confirm the previous finding of an association between GRIK4 and GNB3 variants (rs195478 and rs5443) and remission and treatment resistance in major depression, using a multicenter sample of 223 patients. We did not find any supporting evidence for such associations. These conflicting data may result from difficulties in the replication of candidate gene association studies. |
| Databáze: | OpenAIRE |
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