Cytotoxicity of 213Bi- and 225Ac-immunoconjugates
| Autor: | F M Kaspersen, A V Doornmalen, Roger Molinet, Christos Apostolidis, M W Geerlings, E Bos |
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| Rok vydání: | 1995 |
| Předmět: |
Actinium
Immunoconjugates Cell Survival Immunoglobulin G Cell Line Mice Antibody Specificity Tumor Cells Cultured Cytotoxic T cell Animals Humans Radiology Nuclear Medicine and imaging Cytotoxicity Radioisotopes biology Chemistry Dose-Response Relationship Radiation General Medicine Pentetic Acid In vitro Dose–response relationship Kinetics Cell culture Toxicity Immunology biology.protein Cancer research Carcinoma Squamous Cell Antibody Bismuth |
| Zdroj: | Nuclear medicine communications. 16(6) |
| ISSN: | 0143-3636 |
| Popis: | This paper describes in vitro cytotoxicity experiments with 213Bi- and 225Ac-immunoconjugates on the human epidermoid tumour cell line A431 using a blood group A-reactive murine IgG (2D11) as the specific antibody and MOPC 21 as the control antibody. With both radionuclides, specific cell-killing was achieved. The observed cytotoxicity of 213Bi (T1/2 - 47 min) indicates that this radionuclide is a useful alternative for the alpha-emitter 212Bi in the treatment of blood-borne malignancies. 225Ac-immunoconjugates (T1/2 of 225Ac is 10 days) may be applicable for the treatment of solid tumours, since the daughter radionuclides of 225Ac contribute to the cytotoxic efficacy by a field effect (i.e. toxicity in an area distal from the antibody-binding site). The lack of an adequate chelator for 225Ac is a major drawback. |
| Databáze: | OpenAIRE |
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