Low-intensity exercise diverts cardiac fatty acid metabolism from triacylglycerol synthesis to beta oxidation in fructose-fed rats
| Autor: | Tamara Ivkovic, Goran Koricanac, Mojca Stojiljkovic, Snježana Romić, Tijana Culafic, Milan Kostic, Jelena Stanisic, Snežana Tepavčević |
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| Rok vydání: | 2021 |
| Předmět: |
Fructose fed rats
Fatty acid metabolism Physiology Substrate (chemistry) 030209 endocrinology & metabolism Fructose General Medicine Lipid storage 3. Good health 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine chemistry 030220 oncology & carcinogenesis Physiology (medical) Low intensity exercise Food science Beta oxidation |
| Zdroj: | Archives of Physiology and Biochemistry. :1-11 |
| ISSN: | 1744-4160 1381-3455 |
| Popis: | Excessive fructose consumption causes ectopic lipid storage leading to metabolic disorders and cardiovascular diseases associated with defective substrate utilisation in the heart.Examining the preventive impact of low-intensity exercise on alterations related to fructose-rich diet (FRD) on cardiac fatty acid (FA) transport and metabolism.Male Wistar rats were divided into control and two groups that received 10% fructose for 9 weeks, one of which was additionally exposed to exercise.FRD elevated plasma and cardiac TAG, FATP1 in plasma membrane, Lipin 1 in microsomes and HSL mRNA, while mitochondrial CPT1 was decreased. Exercise decreased plasma free FA level, raised CD36 in plasma membrane and FATP1 in lysate, mitochondrial CPT1 and decreased microsomal Lipin 1 in fructose-fed rats.FRD changed plasma lipids and augmented partitioning of FA to TAG storage in the heart, whereas exercise in FRD rats switched metabolism of FA towards β-oxidation. |
| Databáze: | OpenAIRE |
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