Molecular profiles of non-small cell lung cancers in cigarette smoking and never-smoking patients
| Autor: | Thomas Muley, M Jarząb, Michael Meister, Rafael Rosell, Hendrik Dienemann, Ryszard Pawłowski, Witold Rzyman, Ewa Jassem, Miquel Taron, Amelia Szymanowska-Narloch, Robert Rzepko, M. Skrzypski, Tomasz Marjański, Jacek Jassem |
|---|---|
| Rok vydání: | 2013 |
| Předmět: |
Adult
Male Oncology medicine.medical_specialty Lung Neoplasms Receptors Cell Surface CDKN2A Carcinoma Non-Small-Cell Lung Internal medicine Gene expression Survivin Carcinoma medicine Humans Lung cancer Aged Aged 80 and over Lung Reverse Transcriptase Polymerase Chain Reaction business.industry Phosphotransferases Smoking General Medicine Sex hormone receptor Middle Aged medicine.disease respiratory tract diseases Gene Expression Regulation Neoplastic medicine.anatomical_structure Real-time polymerase chain reaction Intercellular Signaling Peptides and Proteins Female Transcriptome business Transcription Factors |
| Zdroj: | Advances in Medical Sciences. 58:196-206 |
| ISSN: | 1896-1126 |
| Popis: | Purpose: Molecular features of non-small cell lung cancer (NSCLC) in never-smokers are not well recognized. We assessed the expression of genes potentially related to lung cancer etiology in smoking vs. never-smoking NSCLC patients. Methods: We assayed frozen tumor samples from surgically resected 31 never-smoking and 54 clinically pair-matched smoking NSCLC patients, and from corresponding normal lung tissue from 27 and 43 patients, respectively. Expression of 21 genes, including cell membrane kinases, sex hormone receptors, transcription factors, growth factors and others was assessed by reverse transcription – quantitative PCR. Results: Expression of 5 genes was significantly higher in tumors of non-smokers vs. smokers: CSF1R (p |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect