Tula hantavirus NSs protein accumulates in the perinuclear area in infected and transfected cells
| Autor: | Janica Djupsjöbacka, Alexander Plyusnin, Antti Vaheri, Kirsi M. Jääskeläinen, Jussi Oskari Virtanen |
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| Rok vydání: | 2009 |
| Předmět: |
Small RNA
Orthohantavirus viruses Hantavirus Infections Molecular Sequence Data Viral Nonstructural Proteins Transfection Virus Cell Line Interferon Virology Chlorocebus aethiops medicine Animals Humans Hantavirus Cell Nucleus biology General Medicine biology.organism_classification Molecular biology Transport protein Open reading frame Protein Transport Bunyaviridae Tula virus medicine.drug |
| Zdroj: | Archives of virology. 155(1) |
| ISSN: | 1432-8798 |
| Popis: | The small RNA segment of some hantaviruses (family Bunyaviridae) encodes two proteins: the nucleocapsid protein and, in an overlapping reading frame, a non-structural (NSs) protein. The hantavirus NSs protein, like those of orthobunya- and phleboviruses, counteracts host innate immunity. Here, for the first time, the NSs protein of a hantavirus (Tula virus) has been observed in infected cells and shown to localize in the perinuclear area. Transiently expressed NSs protein showed similar localization, although the kinetics was slightly different, suggesting that to reach its proper location in the infected cell, the NSs protein does not have to cooperate with other viral proteins. |
| Databáze: | OpenAIRE |
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