Immunoglobulin G subclasses in antibody responses to St. Louis encephalitis virus infections
| Autor: | Adrián Alejandro Farías, Marta S. Contigiani, Juan Javier Aguilar, Lorena Spinsanti, María del Pilar Díaz |
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| Rok vydání: | 2011 |
| Předmět: |
Time Factors
Encephalitis Virus St. Louis Antibodies Viral Immunofluorescence Virus Immunoglobulin G Immune system Virology parasitic diseases medicine Humans Encephalitis St. Louis biology medicine.diagnostic_test General Medicine medicine.disease Isotype Immunoglobulin Isotypes Titer Antibody Formation Immunology biology.protein Antibody Encephalitis |
| Zdroj: | Archives of Virology. 156:1861-1864 |
| ISSN: | 1432-8798 0304-8608 |
| Popis: | The aim of this study was to recognize the specific antiviral response patterns of IgG1, IgG2, IgG3 and IgG4 subclasses, elicited during St. Louis encephalitis virus (SLEV) infection in humans. Eighty-five samples of human sera from 44 patients with SLEV infection were obtained between days 1 and 365 or later, after onset of the disease. These samples were processed by immunofluorescence assay for detection of IgG1-, IgG2-, IgG3- and IgG4-specific antibodies. We demonstrate the presence of all isotypes of IgG for more than a year in patients infected with SLEV. However; isotype IgG1 was present at the highest titers, with a peak between days 8 and 30 after onset of the disease. |
| Databáze: | OpenAIRE |
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