Connectional gradients underlie functional transitions in monkey pre-supplementary motor area
| Autor: | Marco Lanzilotto, Luca Bonini, Davide Albertini, Marzio Gerbella, Alessandro Livi, Monica Maranesi, Carolina Giulia Ferroni |
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| Rok vydání: | 2020 |
| Předmět: |
Male
0301 basic medicine Population Prefrontal Cortex Striatum Motor Activity Biology Gyrus Cinguli Personal Space 03 medical and health sciences 0302 clinical medicine Connectome motor control medicine Animals education Mirror Neurons Anterior cingulate cortex Mirror neuron education.field_of_study Behavior Animal Supplementary motor area Action observation Neuroanatomy Pre-sma General Neuroscience Putamen Motor Cortex Motor control Macaca mulatta Corpus Striatum Neuroanatomical Tract-Tracing Techniques 030104 developmental biology medicine.anatomical_structure nervous system Visual Perception Electrocorticography Macaca nemestrina Nerve Net Neuroscience 030217 neurology & neurosurgery |
| Zdroj: | Progress in Neurobiology |
| ISSN: | 0301-0082 |
| DOI: | 10.1016/j.pneurobio.2019.101699 |
| Popis: | The pre-supplementary motor area F6 is involved in a variety of functions in multiple domains, from planning/withholding goal-directed actions in space to rule-based cognitive processes and social interactions. Yet, the neural machinery underlying this functional heterogeneity remains unclear. Here, we measured local population dynamics in different rostro-caudal sites of cytoarchitectonically verified area F6 in two monkeys during spatial, contextual and motor processes, both in individual and social conditions. Then, we correlated multimodal population tuning with local anatomical connectivity revealed by neural tracer injections into the functionally characterized sites. We found stronger tuning for object position relative to the monkey in the rostral portion of area F6 than in its caudal part, which in turn exhibits stronger tuning to self and other's (observed) action. Functional specificities were associated with a rostro-caudal transition in connectivity strength from lateral prefrontal cortex, pregenual anterior cingulate cortex and associative striatum (rostrally), to dorso-ventral premotor areas and the motor putamen (caudally). These findings suggest that the functional heterogeneity of the pre-supplementary area F6 is accounted for by gradual transitions in functional properties grounded on local cortico-cortical and cortico-striatal connectional specificities. |
| Databáze: | OpenAIRE |
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